Ostm1 Gene Summary [Rat]
Predicted to be involved in osteoclast differentiation and transepithelial chloride transport. Predicted to be located in lysosomal membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 5. Orthologous to human OSTM1 (osteoclastogenesis associated transmembrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ostm1 |
| Official Name | osteoclastogenesis associated transmembrane protein 1 [Source:RGD Symbol;Acc:1564976] |
| Ensembl ID | ENSRNOG00000037647 |
| Bio databases IDs | |
| Aliases | osteoclastogenesis associated transmembrane protein 1 |
| Synonyms | 1200002H13Rik, GIPN, GL, HSPC019, LOC100362414, OPTB5, osteoclastogenesis associated transmembrane protein 1, osteopetrosis associated transmembrane protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ostm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Osteopetrosis-associated transmembrane protein 1 precursor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive osteopetrosis type 5
- psoriasis
- reactive gliosis
- astigmatism
role in cell
- expression in
- accumulation in
- survival
- accumulation
- maturation
- activation
- quantity
- cell viability
- differentiation
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ostm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast differentiation
- transepithelial chloride transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding