Adam19 Gene Summary [Rat]
Predicted to enable SH3 domain binding activity and metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in several processes, including amyloid precursor protein catabolic process; positive regulation of cell-cell adhesion mediated by cadherin; and proteolysis. Predicted to act upstream of or within heart development. Predicted to be located in Golgi apparatus and nucleus. Orthologous to human ADAM19 (ADAM metallopeptidase domain 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam19 |
| Official Name | ADAM metallopeptidase domain 19 [Source:RGD Symbol;Acc:1585017] |
| Ensembl ID | ENSRNOG00000042980 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 19 |
| Synonyms | ADAM metallopeptidase domain 19, FKSG34, MADDAM, meltrin beta, meltrin β, MLTNB, MTLNB, Sox30 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- ZnMc
- protease domain
- cytoplasmic domain
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- peptidase
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- protein binding
- SH3-domain binding
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adam19 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- brain neoplasm
- cholelithiasis
- angioimmunoblastic T-cell lymphoma
- cancer
- psoriasis
- renal cell cancer
- overall survival
- bipolar disorder
- laser induced choroidal neovascularization
role in cell
- expression in
- cellular infiltration by
- colony formation
- formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Nucleus
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amyloid precursor protein catabolic process
- membrane protein ectodomain proteolysis
- positive regulation of gene expression
- protein processing
- placenta development
- positive regulation of cell-cell adhesion mediated by cadherin
Cellular Component
Where in the cell the gene product is active
- nucleus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- SH3 domain binding
- metalloendopeptidase activity