Fubp1 Gene Summary [Rat]
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and mRNA binding activity. Involved in cellular response to lipopolysaccharide; positive regulation of Schwann cell migration; and response to nutrient levels. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; nucleus; and synapse. Biomarker of sciatic neuropathy and traumatic brain injury. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human FUBP1 (far upstream element binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fubp1 |
| Official Name | far upstream element binding protein 1 [Source:RGD Symbol;Acc:1591892] |
| Ensembl ID | ENSRNOG00000043370 |
| Bio databases IDs | |
| Aliases | far upstream element binding protein 1 |
| Synonyms | 9530027K12Rik, D3ERTD330E, DNA helicase V, far upstream element binding protein 1, far upstream element (FUSE) binding protein 1, FBP, FBP-1, FUBP, Fubp4, hDH V |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fubp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- single-stranded DNA binding
- K homology (KH) RNA-binding domain, type I
- KH domain
- nucleic acid binding
- double-stranded DNA binding
- central domain
- protein binding
- K homology RNA-binding domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- 1p/19q co-deletion positive IDH mutation positive oligodendroglioma
- glioma formation
- non-small cell lung cancer
- Waldenström macroglobulinemia
- hypoplasia
- cardiac hypertrophy
- organismal death
- rheumatoid arthritis
- bleeding
- lung carcinoma
role in cell
- expression in
- proliferation
- number
- apoptosis
- cell viability
- function
- migration by
- cell division
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fubp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression
- regulation of gene expression
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- single-stranded DNA binding