Foxl1 Gene Summary [Rat]
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | Foxl1 |
| Official Name | forkhead box L1 [Source:RGD Symbol;Acc:1584212] |
| Ensembl ID | ENSRNOG00000047125 |
| Bio databases IDs | |
| Aliases | forkhead box L1 |
| Synonyms | FKH6, FKHL11, forkhead box L1, FREAC7, OTSC11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Foxl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- otosclerosis type 11
- clear cell sarcoma of the kidney
- renal cancer
- soft tissue sarcoma cancer
- congenital heart disease
- pancreatic neoplasm
- pancreatic neoplasia
role in cell
- proliferation
- quantity
- expression in
- growth
- invasion
- migration
- invasion by
- gel contraction by
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Foxl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- Peyer's patch morphogenesis
- visceral mesoderm-endoderm interaction involved in midgut development
- cell differentiation
- anatomical structure morphogenesis
- regulation of Wnt receptor signaling pathway
- proteoglycan biosynthetic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- DNA binding, bending
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity