Foxl1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including Peyer's patch morphogenesis; proteoglycan biosynthetic process; and visceral mesoderm-endoderm interaction involved in midgut development. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in otosclerosis 11. Orthologous to human FOXL1 (forkhead box L1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxl1 |
| Official Name | forkhead box L1 [Source:MGI Symbol;Acc:MGI:1347469] |
| Ensembl ID | ENSMUSG00000097084 |
| Bio databases IDs | |
| Aliases | forkhead box L1 |
| Synonyms | FKH6, FKHL11, forkhead box L1, FREAC7, OTSC11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- otosclerosis type 11
- clear cell sarcoma of the kidney
- renal cancer
- soft tissue sarcoma cancer
- congenital heart disease
- pancreatic neoplasm
- pancreatic neoplasia
role in cell
- proliferation
- quantity
- expression in
- growth
- invasion
- migration
- invasion by
- gel contraction by
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- Peyer's patch morphogenesis
- visceral mesoderm-endoderm interaction involved in midgut development
- cell differentiation
- anatomical structure morphogenesis
- regulation of Wnt receptor signaling pathway
- proteoglycan biosynthetic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- DNA binding, bending
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity