Inpp5e Gene Summary [Rat]
Enables inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate phosphatase activity. Involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and negative regulation of translation. Located in ruffle. Biomarker of obesity. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Inpp5e |
| Official Name | inositol polyphosphate-5-phosphatase E [Source:RGD Symbol;Acc:620478] |
| Ensembl ID | ENSRNOG00000019039 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-5-phosphatase E |
| Synonyms | 1200002L24Rik, 5PTASE4, CORS1, CPD4, inositol polyphosphate-5-phosphatase E, JBTS1, mKIAA0123, MORMS, pharbin, PIP2 5-PHOSPHATASE, PPI5PIV |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Inpp5e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CAAX box
- inositol-polyphosphate 5-phosphatase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
- phosphatase
- protein binding
- phosphoinositide 5-phosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hereditary disorder
- Joubert syndrome type 1
- inflammatory bowel disease
- skin squamous cell carcinoma
- squamous cell skin cancer
- retinal dystrophy
- hypoplasia
- Joubert syndrome related disorder
- cleft palate
role in cell
- apoptosis
- instability
- assembly
- morphology
- abnormal morphology
- loss
- binding in
- translation in
- spindle checkpoint in
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cilia
- perinuclear region
- Nucleus
- axonemes
- cytosol
- Golgi membrane
- Golgi stacks
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Inpp5e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol biosynthetic process
- negative regulation of translation
- negative regulation of protein kinase B signaling cascade
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- Golgi cisterna membrane
- ruffle
- cilium
- cytosol
- Golgi membrane
- Golgi apparatus
- axoneme
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
- inositol-polyphosphate 5-phosphatase activity
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity