Cpne1 Gene Summary [Rat]
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | Cpne1 |
| Official Name | copine 1 [Source:RGD Symbol;Acc:1311148] |
| Ensembl ID | ENSRNOG00000050864 |
| Bio databases IDs | |
| Aliases | copine 1 |
| Synonyms | 1810028N16Rik, copine, Copine1, copine I, COPN1, CPN1, LOC100910990, mKIAA4108 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpne1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- von Willebrand factor (vWF) type A domain
- NF-kappaB binding
- peptidase
- calcium ion binding
- calcium-dependent phospholipid binding
- protein binding
- identical protein binding
- Copine
- endopeptidase
- binding protein
- vWFA
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- renal clear cell adenocarcinoma
- renal clear cell cancer
- atopic dermatitis
role in cell
- migration
- phosphorylation in
- invasion by
- proliferation
- differentiation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- secretory granule membrane
- cytosol
- lysosome membrane
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpne1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- negative regulation of DNA binding
- vesicle-mediated transport
- cellular response to calcium ion
- proteolysis
- lipid metabolic process
- regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of neuron differentiation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- azurophil granule membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- identical protein binding
- phosphatidylserine binding
- protein binding
- calcium ion binding
- endopeptidase activity
- calcium-dependent phospholipid binding