Fgfr1op Gene Summary [Rat]
Predicted to enable protein homodimerization activity; protein kinase binding activity; and protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; positive regulation of cell growth; and positive regulation of cell migration. Predicted to be located in centriole; nucleus; and perinuclear region of cytoplasm. Predicted to be active in centrosome. Orthologous to human CEP43 (centrosomal protein 43). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgfr1op |
| Official Name | Fgfr1 oncogene partner [Source:RGD Symbol;Acc:1583370] |
| Ensembl ID | ENSRNOG00000055093 |
| Bio databases IDs | |
| Aliases | Fgfr1 oncogene partner |
| Synonyms | 4930553O10Rik, centrosomal protein 43, FGFR1OP, FOP, LOC683722 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgfr1op often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein kinase binding
- protein tyrosine kinase inhibitor activity
- Lissencephaly type1-like homology motif
- protein homodimerization
- protein binding
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- Crohn disease
- epithelial basal cell carcinoma
- IgA nephropathy
- skin neoplasm
- skin neoplasia
- androgenic alopecia
- myeloproliferative disorder
- lichen planus
role in cell
- migration
- proliferation
- growth
- formation
- survival
- anchoring
- formation in
- disorganization
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centriolar satellite
- perinuclear region
- Nucleus
- basal bodies
- centrosome
- centriole
- cytosol
- spindle pole
- spindle fibers
- plus end of microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgfr1op gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell growth
- microtubule anchoring
- cell projection organization
- positive regulation of cell proliferation
- negative regulation of protein kinase activity
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- centriole
- cytosol
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein homodimerization activity
- protein tyrosine kinase inhibitor activity