Azgp1 Gene Summary [Rat]
Involved in cellular response to insulin stimulus and cellular response to magnesium ion. Predicted to be active in external side of plasma membrane and extracellular space. Biomarker of chronic kidney disease; epilepsy; liver disease (multiple); obesity; and rheumatoid arthritis. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human AZGP1 (alpha-2-glycoprotein 1, zinc-binding). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Azgp1 |
| Official Name | alpha-2-glycoprotein 1, zinc-binding [Source:RGD Symbol;Acc:2187] |
| Ensembl ID | ENSRNOG00000001333 |
| Bio databases IDs | |
| Aliases | alpha-2-glycoprotein 1, zinc-binding |
| Synonyms | alpha2 GLYCOPROTEIN 1, alpha-2-glycoprotein 1, zinc, alpha-2-glycoprotein 1, zinc-binding, Lipid Mobilising Factor, Lipid Mobilizing Factor, LMF, ZA2G, ZA2GA, ZAG, Zinc Alpha 2 Glycoprotein, Zinc-alpha-2-glycoprotein, chain D, Zinc-α 2-glycoprotein, Zinc-α-2-glycoprotein, chain D, Zna2gp, Zn-alpha2-GLYCOPROTEIN, α-2-glycoprotein 1, zinc, α-2-glycoprotein 1, zinc-binding |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Azgp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- immunoglobulin domain
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- neoplasia
- cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- epithelial cancer
- organismal death
- diabetic nephropathy
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- phosphorylation in
- expression in
- degradation in
- downregulation in
- adhesion
- invasiveness
- epithelial-mesenchymal transition
- epithelial to mesenchymal transdifferentiation
- synthesis in
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Azgp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- immune response
- negative regulation of cell proliferation
- detection of chemical stimulus involved in sensory perception of bitter taste
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- external side of plasma membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein transmembrane transporter activity
- ribonuclease activity