Klrb1 Gene Summary [Rat]
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in NK T cell activation and regulation of natural killer cell mediated cytotoxicity. Predicted to be active in cell surface and plasma membrane. Orthologous to several human genes including KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klrb1 |
| Official Name | killer cell lectin-like receptor subfamily B, member 1 [Source:RGD Symbol;Acc:1587563] |
| Ensembl ID | ENSRNOG00000057410 |
| Bio databases IDs | |
| Aliases | killer cell lectin-like receptor subfamily B, member 1 |
| Synonyms | 4930431A04Rik, CD161, CLEC5B, Gm4696, hNKR-P1A, killer cell lectin like receptor B1, killer cell lectin-like receptor subfamily B member 1, Klrb1d, Klrb1f, Klrb1g, Klrb6, LOC100048690, LOC683766, Ly-55, NKR, NKR-P1, NKR-P1A, Nkr-p1e, NKR-P1G |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klrb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- cytoplasmic domain
- ectodomain
- Lectin C-type domain
- protein binding
- carbohydrate binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Klrb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- epithelial cancer
- urothelial bladder carcinoma
- systemic lupus erythematosus
- acute myeloid leukemia
- hepatocellular carcinoma
- sarcoidosis
- sepsis
- organismal death
- renal clear cell adenocarcinoma
role in cell
- apoptosis
- production in
- signaling in
- proliferation
- invasion by
- migration
- S phase progression
- secretion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klrb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- signaling receptor activity
- carbohydrate binding