Fgd4 Gene Summary [Rat]
Enables actin filament binding activity. Involved in positive regulation of JNK cascade and regulation of cell shape. Acts upstream of or within positive regulation of JUN kinase activity. Predicted to be located in filopodium and lamellipodium. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgd4 |
| Official Name | FYVE, RhoGEF and PH domain containing 4 [Source:RGD Symbol;Acc:708357] |
| Ensembl ID | ENSRNOG00000059491 |
| Bio databases IDs | |
| Aliases | FYVE, RhoGEF and PH domain containing 4 |
| Synonyms | 9030023J02RIK, 9330209B17Rik, CMT4H, FRABIN, FRABP, FYVE, RhoGEF and PH domain containing 4, LOC108352368, ZFYVE6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE zinc finger
- enzyme binding
- Pleckstrin homology-like domain
- RhoGEF domain
- FYVE domain like superfamily
- actin filament binding
- RhoGEF
- actin-binding domain
- Fab domain
- Protein present in Fab1, YOTB, Vac1, and EEA1
- actin binding
- guanyl-nucleotide exchange factor
- PH domain
- PHD finger superfamily
- Dbl homology domain
- cysteine rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hypertension
- Charcot-Marie-Tooth disease type 4
- hereditary disorder
- Charcot-Marie-Tooth disease type 4h
- carcinoma in situ
- epithelial cancer in situ
- demyelination
- suicide attempt
- cerebral atherosclerosis
role in cell
- activation in
- formation
- action potential
- migration
- abnormal morphology
- number
- invasion
- shape change
- motility
- endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Golgi Apparatus
- cytosol
- membrane ruffles
- filopodia
- lamellipodia
- detergent-soluble fraction
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- filopodium assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- ruffle
- cytosol
- filopodium
- Golgi apparatus
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin binding
- metal ion binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding