Hmmr Gene Summary [Rat]
Predicted to enable cargo receptor activity. Predicted to be involved in hyaluronan catabolic process and receptor-mediated endocytosis. Predicted to be located in centrosome; cytosol; and spindle. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human HMMR (hyaluronan mediated motility receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmmr |
| Official Name | hyaluronan-mediated motility receptor [Source:RGD Symbol;Acc:2805] |
| Ensembl ID | ENSRNOG00000059894 |
| Bio databases IDs | |
| Aliases | hyaluronan-mediated motility receptor |
| Synonyms | AA386826, CD168, hyaluronan-mediated motility receptor, hyaluronan mediated motility receptor (RHAMM), IHABP, RHAMM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmmr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- chromosome segregation protein SMC, primarily archaeal type
- cargo receptor activity
- Hyaluronan mediated motility receptor N-terminal
- Hyaluronan mediated motility receptor C-terminal
- helix-rich Mycoplasma protein
- protein binding
- hyaluronic acid binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Hmmr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- metastasis
- collagen-induced arthritis
- pancreatic neoplasia
- malignant peripheral nerve sheath tumor
- liver cancer
- epithelial cancer
- septic shock
- advanced cancer
role in cell
- expression in
- sphere formation
- phosphorylation in
- growth
- apoptosis
- proliferation
- quantity
- adhesion
- migration
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- spindle apparatus
- cytoskeleton
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- centrosome
- Mitochondria
- microtubules
- cytosol
- spindle pole
- mitotic spindle
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hmmr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- receptor-mediated endocytosis
- hyaluronan catabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- microtubule cytoskeleton
- membrane
- spindle
- cytosol
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- cargo receptor activity
- hyaluronic acid binding