Il7 Gene Summary [Rat]
Predicted to enable cytokine activity and growth factor activity. Involved in cellular response to hypoxia and response to X-ray. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Used to study high grade glioma. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in immunodeficiency 130. Orthologous to human IL7 (interleukin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il7 |
| Official Name | interleukin 7 [Source:RGD Symbol;Acc:2904] |
| Ensembl ID | ENSRNOG00000011973 |
| Bio databases IDs | |
| Aliases | interleukin 7 |
| Synonyms | A630026I06RIK, hlb368, IMD130, interleukin 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-7 receptor binding
- Interleukin 7
- protein binding
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the Il7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- B Cell Development
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- IL-7 Signaling Pathway
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- neoplasia
- osteoporosis
- infection
- metastasis
- pruritus
- alopecia areata
- glioblastoma
- glioblastoma cancer
- renal clear cell adenocarcinoma
role in cell
- cell death
- signaling in
- apoptosis
- proliferation
- activation in
- expression in
- phosphorylation in
- tyrosine phosphorylation in
- quantity
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Plasma Membrane
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- organ growth
- positive regulation of cell proliferation
- interleukin-7-mediated signaling pathway
- positive regulation of organ growth
- cell-cell signaling
- extrinsic apoptotic signaling pathway
- B cell proliferation
- T cell lineage commitment
- positive regulation of B cell differentiation
- organ morphogenesis
- positive regulation of cytokine-mediated signaling pathway
- regulation of peptidyl-tyrosine phosphorylation
- homeostasis of number of cells within a tissue
- bone resorption
- negative regulation of apoptotic process
- positive regulation of T cell differentiation
- cytokine-mediated signaling pathway
- humoral immune response
- positive regulation of B cell proliferation
- positive regulation of chemokine production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interleukin-7 receptor binding
- growth factor activity
- protein binding
- cytokine activity