Gdpd1 Gene Summary [Rat]
Predicted to enable lysophospholipase activity and phosphoric diester hydrolase activity. Predicted to be involved in N-acylethanolamine metabolic process and glycerophospholipid catabolic process. Predicted to act upstream of or within phospholipid metabolic process. Predicted to be located in endoplasmic reticulum; membrane; and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human GDPD1 (glycerophosphodiester phosphodiesterase domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdpd1 |
| Official Name | glycerophosphodiester phosphodiesterase domain containing 1 [Source:RGD Symbol;Acc:1311813] |
| Ensembl ID | ENSRNOG00000060561 |
| Bio databases IDs | |
| Aliases | glycerophosphodiester phosphodiesterase domain containing 1 |
| Synonyms | 2610020H15RIK, FLJ37451, GDE4, glycerophosphodiester phosphodiesterase domain containing 1, RGD1311813 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gdpd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysophospholipase
- Glycerophosphoryl diester phosphodiesterase family
- enzyme
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the Gdpd1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- ocular hypertension
- hepatocellular carcinoma
regulates
- N-acylethanolamine
- 1-alkyl-2-lyso-sn-glycero-3-phosphocholine
- 1-alkyl-lysophosphatidic acid
- lysophosphatidic acid
- lysophosphatidylcholine
- phospholipid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gdpd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerophospholipid catabolic process
- N-acylethanolamine metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- metal ion binding
- phosphoric diester hydrolase activity