Ppp1r12b Gene Summary [Rat]
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be involved in neuron projection morphogenesis. Predicted to be located in stress fiber. Predicted to be active in A band and Z disc. Orthologous to human PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r12b |
| Official Name | protein phosphatase 1, regulatory subunit 12B [Source:RGD Symbol;Acc:1309287] |
| Ensembl ID | ENSRNOG00000051440 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 12B |
| Synonyms | 1810037O03RIK, 9530009M10RIK, A330043L12, AI132431, CHROMOSOME 1 SPECIFIC transcript KIAA0503, M-COMPLEX 25KDA subunit, MYPT2, PP1bp55, protein phosphatase 1 regulatory subunit 12B, protein phosphatase 1, regulatory subunit 12B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp1r12b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cGMP-dependent protein kinase interacting domain
- Ankyrin repeats (many copies)
- phosphatase
- Ankyrin repeats (3 copies)
- protein binding
- IPD_PPP1R12
- enzyme activator activity
- MLCP
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Ppp1r12b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- CCR3 Signaling in Eosinophils
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Estrogen Receptor Signaling
- Integrin Signaling
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- celiac disease
- breast carcinoma
- acne
- mitral valve prolapse
- open-angle glaucoma
- chronic obstructive pulmonary disease
- endometrial cancer
- coronary artery disease
- autosomal dominant polycystic kidney disease
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actomyosin filament
- sarcomere
- cytosol
- nucleoplasm
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp1r12b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of muscle contraction
Cellular Component
Where in the cell the gene product is active
- Z disc
- cytoplasm
- stress fiber
- cytosol
- A band
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- phosphatase regulator activity
- protein binding
- enzyme inhibitor activity
- enzyme activator activity