L1cam Gene Summary [Rat]
Enables PDZ domain binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to ethanol; and neuron differentiation. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Is active in Schaffer collateral - CA1 synapse. Used to study hydrocephalus. Biomarker of anxiety disorder; depressive disorder; and hypothyroidism. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | L1cam |
| Official Name | L1 cell adhesion molecule [Source:RGD Symbol;Acc:619777] |
| Ensembl ID | ENSRNOG00000061230 |
| Bio databases IDs | |
| Aliases | L1 cell adhesion molecule |
| Synonyms | CAML1, CD171, HSAS, HSAS1, HYCX, Hyd, L1, L1 cell adhesion molecule, L1 isoform, MASA, MIC5, N-CAM-L1, NEUROGLIAN, NgCAM, S10, SPG1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat L1cam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- RSLE motif
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- protein domain specific binding
- Fibronectin type 3 domain
- protein binding
- identical protein binding
- PDZ-domain binding
- phosphorylation site
- binding protein
- cytoplasmic domain
- FN3
- Immunoglobulin like
- integrin binding
- transmembrane domain
- immunoglobulin-like protein domain
- intracellular domain
- Bravo-like intracellular region
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the L1cam gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- neoplasia
- metastasis
- X-linked hydrocephalus syndrome
- spastic paraplegia
- CRASH syndrome
- Waldenström macroglobulinemia
- X-linked partial agenesis of corpus callosum
- weight gain
- hypoplasia
role in cell
- activation in
- apoptosis
- differentiation
- expression in
- extension
- phosphorylation in
- proliferation
- development
- production in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- myelin enriched fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- axon component
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- actin filaments
- cell-cell contacts
- plasma membrane extracellular face
- presynaptic membrane
- dendritic spine head
- synaptic vesicles
- growth cone
- synapse
- cytoplasmic vesicles
- extracellular matrix
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- axon terminals
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat L1cam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- chemotaxis
- neuron projection development
- synapse organization
- nervous system development
- axon guidance
- positive regulation of axon extension
- cell adhesion
- homophilic cell adhesion
- cell migration
Cellular Component
Where in the cell the gene product is active
- dendrite
- focal adhesion
- axonal growth cone
- neuronal cell body
- axon
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- axon guidance receptor activity