Ccr2 Gene Summary [Mouse]
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including mononuclear cell migration; positive regulation of cell migration; and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response; monocyte chemotaxis; and regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr2 |
| Official Name | chemokine (C-C motif) receptor 2 [Source:MGI Symbol;Acc:MGI:106185] |
| Ensembl ID | ENSMUSG00000049103 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 2 |
| Synonyms | CC-CKR-2, C-C motif chemokine receptor 2, Ccr2a, Ccr2b, CD192, CHEMOKINE CC2 receptor, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, mJe-r, PCLUD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- cytokine binding
- CCR chemokine receptor binding
- chemokine receptor binding domain
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- phosphorylation site
- C-C chemokine receptor
- chemokine receptor
- C-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ccr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cancer
- weight gain
- fibrosis
- epithelial cancer
- epithelial neoplasia
- prostate cancer
- abdominal cancer
- urogenital cancer
phenotypes
- enlarged heart
- abnormal Bruch membrane morphology
- abnormal Langerhans cell physiology
- abnormal bone mineral density
- abnormal bone trabecula morphology
- abnormal cellular extravasation
- abnormal chemokine secretion
- abnormal cholesterol homeostasis
- abnormal choriocapillaris morphology
- abnormal conditioned taste aversion behavior
- abnormal cytokine secretion
- abnormal dendritic cell chemotaxis
- abnormal glucose homeostasis
- abnormal immune serum protein physiology
- abnormal leukocyte adhesion
- abnormal leukocyte migration
- abnormal leukocyte physiology
- abnormal lipid homeostasis
- abnormal macrophage chemotaxis
- abnormal macrophage morphology
- abnormal microglial cell physiology
- abnormal monocyte morphology
- abnormal optic choroid morphology
- abnormal osteoclast cell number
- abnormal osteoclast differentiation
- abnormal osteoclast physiology
- abnormal podocyte morphology
- abnormal renal glomerulus morphology
- abnormal retinal pigment epithelium morphology
- abnormal spleen morphology
- abnormal trabecular bone morphology
- abnormal urine protein level
- abnormal vascular wound healing
- abnormal wound healing
- alcohol aversion
- altered response to myocardial infarction
- bronchiolitis
- choroidal neovascularization
- decreased CD11b-high dendritic cell number
- decreased CD4-positive alpha beta T cell number
- decreased T cell proliferation
- decreased acute inflammation
- decreased airway responsiveness
- decreased alcohol consumption
- decreased circulating creatinine level
- decreased common myeloid progenitor cell number
- decreased inflammatory response
- decreased interferon-gamma secretion
- decreased interleukin-2 secretion
- decreased interleukin-6 secretion
- decreased macrophage cell number
- decreased monocyte cell number
- decreased neutrophil cell number
- decreased osteoclast cell number
- decreased splenocyte proliferation
- decreased susceptibility to bone fracture
- decreased susceptibility to experimental autoimmune encephalomyelitis
- decreased susceptibility to induced colitis
- decreased susceptibility to kidney reperfusion injury
- decreased susceptibility to type I hypersensitivity reaction
- decreased tumor growth/size
- diarrhea
- enlarged liver
- enlarged spleen
- hepatic necrosis
- impaired leukocyte tethering or rolling
- impaired macrophage chemotaxis
- increased B cell number
- increased CD11b-high dendritic cell number
- increased CD8-positive alpha-beta T cell number
- increased IgG level
- increased alcohol consumption
- increased circulating alanine transaminase level
- increased dendritic cell number
- increased eosinophil cell number
- increased fluid intake
- increased hepatocyte apoptosis
- increased interferon-gamma secretion
- increased physiological sensitivity to xenobiotic
- increased susceptibility to Coronaviridae infection
- increased susceptibility to Coronaviridae infection induced morbidity/mortality
- increased susceptibility to bacterial infection
- increased susceptibility to induced colitis
- increased trabecular bone thickness
- increased trabecular bone volume
- increased tumor necrosis factor secretion
- lipofuscinosis
- liver hemorrhage
- liver inflammation
- multifocal hepatic necrosis
- retinal degeneration
- retinal deposits
- retinal outer nuclear layer degeneration
- retinal photoreceptor degeneration
- weight loss
role in cell
- apoptosis
- production in
- expression in
- activation in
- recruitment
- number
- proliferation
- density
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fibrillar center
- Cytoplasm
- cell surface
- Extracellular Space
- apical compartment
- perinuclear region
- cellular membrane
- filamentous network
- plasma membrane extracellular face
- cell membrane leading edge
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of adenylate cyclase activity
- negative regulation of angiogenesis
- hemopoiesis
- response to wounding
- JAK-STAT cascade
- cell chemotaxis
- chemotaxis
- positive regulation of monocyte extravasation
- positive regulation of T cell activation
- inflammatory response
- immune response
- positive regulation of alpha-beta T cell proliferation
- cytokine-mediated signaling pathway
- humoral immune response
- positive regulation of interferon-gamma production
- positive regulation of tumor necrosis factor production
- positive regulation of CD8-positive, alpha-beta T cell extravasation
- positive regulation of synaptic transmission, glutamatergic
- calcium-mediated signaling
- positive regulation of hematopoietic stem cell migration
- regulation of vascular endothelial growth factor production
- positive regulation of thymocyte migration
- positive regulation of interleukin-2 production
- cellular homeostasis
- monocyte extravasation
- positive regulation of monocyte chemotaxis
- positive regulation of immune complex clearance by monocytes and macrophages
- positive regulation of inflammatory response
- negative regulation of eosinophil degranulation
- elevation of cytosolic calcium ion concentration
- cellular calcium ion homeostasis
- regulation of T cell differentiation
- cellular defense response
- blood vessel remodeling
- T-helper 17 cell chemotaxis
- homeostasis of number of cells within a tissue
- monocyte chemotaxis
- regulation of T cell cytokine production
- chemokine-mediated signaling pathway
- dendritic cell chemotaxis
- positive regulation of T cell chemotaxis
- positive regulation of T-helper 1 type immune response
- positive regulation of astrocyte chemotaxis
- sensory perception of pain
- regulation of inflammatory response
- negative regulation of type 2 immune response
Cellular Component
Where in the cell the gene product is active
- dendrite
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- external side of plasma membrane
- cytosol
- neuronal cell body
- perikaryon
- plasma membrane
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- identical protein binding
- protein binding
- chemokine (C-C motif) ligand 12 binding
- chemokine (C-C motif) ligand 7 binding
- CCR2 chemokine receptor binding
- C-C chemokine receptor activity
- chemokine (C-C motif) ligand 2 binding
- chemokine receptor activity