Pes1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Acts upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus organization; and protein localization to organelle. Located in condensed chromosome and nucleolus. Part of PeBoW complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human PES1 (pescadillo ribosomal biogenesis factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pes1 |
| Official Name | pescadillo ribosomal biogenesis factor 1 [Source:MGI Symbol;Acc:MGI:1890613] |
| Ensembl ID | ENSMUSG00000020430 |
| Bio databases IDs | |
| Aliases | pescadillo ribosomal biogenesis factor 1 |
| Synonyms | NOP7, PES, Pescadillo, pescadillo ribosomal biogenesis factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pes1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BRCT
- Pescadillo N-terminus
- BRCA1 C Terminus (BRCT) domain
- BRCT domain, a BRCA1 C-terminus domain
- protein binding
- breast cancer carboxy-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- neoplasia
- schizophrenia
- organismal death
- dementia
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- gastric epithelial cancer
role in cell
- proliferation
- expression in
- survival
- differentiation
- accumulation
- transformation
- cellular infiltration by
- replication in
- binding in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- Cytoplasm
- cytosol
- chromosome
- prenucleolar bodies
- nucleoplasm
- nucleolus derived foci
- nucleoli
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pes1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- cell proliferation
- ribosomal large subunit biogenesis
- regulation of cell cycle
- rRNA processing
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
Where in the cell the gene product is active
- membrane
- PeBoW complex
- cytosol
- chromosome
- nucleolus
- nucleoplasm
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ribonucleoprotein complex binding