Cxcr2 Gene Summary [Mouse]
Enables chemokine receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; epithelium; and heart. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; WHIM syndrome 2; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxcr2 |
| Official Name | chemokine (C-X-C motif) receptor 2 [Source:MGI Symbol;Acc:MGI:105303] |
| Ensembl ID | ENSMUSG00000026180 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) receptor 2 |
| Synonyms | CD128, CD182, CDW128, CDw128b, CHEMOKINE CXC2 receptor, CMKAR2, C-X-C motif chemokine receptor 2, Gpcr16, IL8R2, IL8RA, IL8RB, IL-8Rh, mIL-8RH, WHIMS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- DRY motif
- interleukin-8 receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- C-X-C chemokine receptor
- chemokine receptor
- transmembrane domain
- intracellular domain
- extracellular loop
- interleukin-8 binding
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- cytosolic tail domain
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Cxcr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- COVID-19
- acute myeloid leukemia
- psoriasis
- lung carcinoma process
- lung cancer
phenotypes
- decreased B cell number
- decreased CD8-positive alpha-beta T cell number
- decreased T cell number
- decreased bone mineral density
- decreased circulating fructosamine level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating thyroxine level
- decreased hematocrit
- decreased immature B cell number
- decreased mature B cell number
- decreased pre-B cell number
- decreased pre-pro B cell number
- decreased total body fat amount
- improved glucose tolerance
- increased CD103-positive CD11b-low dendritic cell number
- increased CD4-positive alpha-beta memory T cell number
- increased CD8-positive alpha-beta memory T cell number
- increased KLRG1+ CD4 alpha beta T cell number
- increased KLRG1+ CD8 alpha beta T cell number
- increased Ly6C high monocyte number
- increased Ly6C low monocyte number
- increased anti-nuclear antigen antibody level
- increased circulating LDL cholesterol level
- increased circulating calcium level
- increased circulating creatinine level
- increased circulating magnesium level
- increased circulating total protein level
- increased effector memory CD8-positive alpha-beta T cell number
- increased effector memory T-helper cell number
- increased eosinophil cell number
- increased gamma-delta T cell number
- increased granulocyte number
- increased lean body mass
- increased memory-marker CD4-positive NK T cell number
- increased memory-marker NK cell number
- increased memory-marker gamma-delta T cell number
- increased monocyte cell number
- increased neutrophil cell number
- abnormal NK T cell physiology
- abnormal T cell physiology
- abnormal T-helper 1 physiology
- abnormal T-helper 2 physiology
- abnormal airway responsiveness
- abnormal bone marrow morphology
- abnormal bone mineral density
- abnormal chemokine level
- abnormal circulating LDL cholesterol level
- abnormal circulating calcium level
- abnormal circulating creatinine level
- abnormal circulating fructosamine level
- abnormal circulating thyroxine level
- abnormal circulating total protein level
- abnormal cytokine secretion
- abnormal eosinophil physiology
- abnormal granulocyte differentiation
- abnormal interleukin level
- abnormal leukocyte physiology
- abnormal myelination
- abnormal myelopoiesis
- abnormal neutrophil physiology
- abnormal respiratory mucosa goblet cell morphology
- abnormal spinal cord morphology
- abnormal spleen white pulp morphology
- abnormal tumor morphology
- corneal vascularization
- decreased airway responsiveness
- decreased body size
- decreased kidney weight
- decreased metastatic potential
- decreased oligodendrocyte progenitor number
- decreased sensitivity to induced morbidity/mortality
- decreased spleen weight
- decreased susceptibility to bacterial infection induced morbidity/mortality
- decreased susceptibility to fungal infection
- decreased susceptibility to induced arthritis
- decreased thymus weight
- decreased tumor growth/size
- delayed wound healing
- enlarged cervical lymph nodes
- enlarged lymph nodes
- enlarged spleen
- extramedullary hematopoiesis
- impaired neutrophil chemotaxis
- impaired neutrophil recruitment
- increased B cell number
- increased IgE level
- increased circulating interleukin-6 level
- increased epididymis weight
- increased kidney weight
- increased leukocyte cell number
- increased seminal vesicle weight
- increased spleen weight
- increased susceptibility to Herpesvirales infection
- increased susceptibility to bacterial infection
- increased susceptibility to parasitic infection
- lymph node medullary cord hyperplasia
- myeloid hyperplasia
- small adrenal glands
- small liver
role in cell
- binding
- phosphorylation in
- activation in
- apoptosis
- proliferation
- growth
- expression in
- induction in
- quantity
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- microtubule cytoskeleton
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- lysosome
- secretory granule membrane
- granules
- apical membrane
- nucleoplasm
- neurites
- mitotic spindle
- perikaryon
- axons
- dendrites
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cxcr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neutrophil activation
- signal transduction
- interleukin-8-mediated signaling pathway
- positive regulation of cell proliferation
- cell surface receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- chemotaxis
- cellular defense response
- inflammatory response
- immune response
- chemokine-mediated signaling pathway
- dendritic cell chemotaxis
- neutrophil chemotaxis
- calcium-mediated signaling
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- microtubule cytoskeleton
- mitotic spindle
- mast cell granule
- membrane
- external side of plasma membrane
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- G-protein coupled receptor activity
- interleukin-8 binding
- protein binding
- C-C chemokine receptor activity
- C-X-C chemokine receptor activity
- interleukin-8 receptor activity