VTN Gene Summary
The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | VTN |
| Official Name | vitronectin [Source:HGNC Symbol;Acc:HGNC:12724] |
| Ensembl ID | ENSG00000109072 |
| Bio databases IDs | |
| Aliases | vitronectin, serum spreading factor, somatomedin B, complement S-protein |
| Synonyms | Aa1018,V75,vitronectin,VN,VNT |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- extracellular matrix binding
- HX
- RGD motif
- heparin binding domain
- extracellular matrix structural constituent
- linker domain
- protein binding
- Somatomedin B domain
- identical protein binding
- integrin binding
- collagen binding
- heparin binding
- PAI-1-binding domain
Pathways
Biological processes and signaling networks where the VTN gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- pituitary gland adenoma
- systemic sclerosis
- colorectal cancer
- liver cancer
- ovarian cancer
- COVID-19
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- Alzheimer disease
role in cell
- expression in
- apoptosis
- aggregation
- synthesis in
- survival
- quantity
- cell death
- formation
- formation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- Golgi lumen
- intracellular membrane-bounded organelle
- cell surface
- focal adhesions
- Endoplasmic Reticulum
- rough endoplasmatic reticulum
- extracellular matrix
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the VTN gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- cell-matrix adhesion
- oligodendrocyte differentiation
- positive regulation of protein binding
- positive regulation of wound healing
- negative regulation of fibrinolysis
- negative regulation of blood coagulation
- cell adhesion
- smooth muscle cell-matrix adhesion
- protein polymerization
- cell adhesion mediated by integrin
- immune response
- vesicle-mediated transport
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- endodermal cell differentiation
- extracellular matrix organization
- negative regulation of endopeptidase activity
- positive regulation of cell-substrate adhesion
- regulation of cell adhesion
- positive regulation of smooth muscle cell migration
- positive regulation of receptor-mediated endocytosis
- cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
cellular COMPONENT
Where in the cell the gene product is active
- basement membrane
- extracellular space
- alphav-beta3 integrin-vitronectin complex
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- blood microparticle
- endoplasmic reticulum
- rough endoplasmic reticulum lumen
- extracellular region
- Golgi lumen
molecular FUNCTION
What the gene product does at the molecular level
- extracellular matrix binding
- identical protein binding
- protein binding
- collagen binding
- scavenger receptor activity
- heparin binding
- integrin binding
- extracellular matrix structural constituent
- polysaccharide binding