ADM Gene Summary [Human]
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Details
| Type | Protein Coding |
| Official Symbol | ADM |
| Official Name | adrenomedullin [Source:HGNC Symbol;Acc:HGNC:259] |
| Ensembl ID | ENSG00000148926 |
| Bio databases IDs | |
| Aliases | adrenomedullin |
| Synonyms | Adm1, ADM precursor, Adrenomedullin, Adrenomedullin precursor, AM, Ap, H39316, RATAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcitonin / CGRP / IAPP family
- G-protein-coupled receptor binding
- hormone
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the ADM gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spontaneous hypertension
- cardiovascular disorder
- hypertension
- rheumatoid arthritis
- metabolic syndrome X
- anorexia
- metastasis
- COVID-19
- neoplasia
- cancer
role in cell
- expression in
- proliferation
- activation in
- phosphorylation in
- cell death
- quantity
- apoptosis
- cell viability
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- granules
- neurites
- secretory granules
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- cell proliferation
- positive regulation of progesterone biosynthetic process
- negative regulation of vasoconstriction
- negative regulation of cell proliferation
- regulation of systemic arterial blood pressure
- positive regulation of cell proliferation
- response to starvation
- odontogenesis of dentin-containing tooth
- vasculogenesis
- positive regulation of angiogenesis
- heart development
- inflammatory response
- response to hypoxia
- response to insulin stimulus
- neural tube closure
- response to glucocorticoid stimulus
- signal transduction
- branching involved in labyrinthine layer morphogenesis
- female pregnancy
- G-protein coupled receptor internalization
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- developmental growth
- negative regulation of vascular permeability
- vascular smooth muscle cell development
- elevation of cytosolic calcium ion concentration
- regulation of the force of heart contraction
- regulation of urine volume
- androgen metabolic process
- positive regulation of apoptotic process
- positive regulation of vasculogenesis
- neuron projection regeneration
- response to lipopolysaccharide
- organ regeneration
- receptor internalization
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- hormone activity
- adrenomedullin receptor binding
- receptor binding