Itpkb Gene Summary [Mouse]
Enables inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Located in cytosol; membrane; and nucleus. Is expressed in alimentary system; facial bone primordium; liver; nervous system; and urinary system. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itpkb |
| Official Name | inositol 1,4,5-trisphosphate 3-kinase B [Source:MGI Symbol;Acc:MGI:109235] |
| Ensembl ID | ENSMUSG00000038855 |
| Bio databases IDs | |
| Aliases | inositol 1,4,5-trisphosphate 3-kinase B |
| Synonyms | 1110033J02RIK, Aw121826, E130307H12RIK, inositol 1,4,5-trisphosphate 3-kinase B, inositol-trisphosphate 3-kinase B, IP3-3KB, IP3 3-kinase B, IP3K, IP3K-B, PIG37 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itpkb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- inositol-trisphosphate 3-kinase
- Inositol polyphosphate kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- Huntington disease
- diarrhea
- Parkinson disease
- allergy
- asthma
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- preeclampsia
role in cell
- number
- proliferation
- phosphorylation in
- differentiation
- survival
- quantity
- accumulation in
- development
- activation
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itpkb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neutrophil apoptotic process
- negative regulation of myeloid cell differentiation
- signal transduction
- phosphatidylinositol phosphorylation
- positive regulation of Ras protein signal transduction
- cell surface receptor signaling pathway
- myeloid cell homeostasis
- positive thymic T cell selection
- positive regulation of alpha-beta T cell differentiation
- inositol trisphosphate metabolic process
- MAPK cascade
- inositol phosphate biosynthetic process
- cellular response to calcium ion
- regulation of protein phosphorylation
- common myeloid progenitor cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- inositol-1,4,5-trisphosphate 3-kinase activity
- inositol tetrakisphosphate kinase activity