Lepr Gene Summary [Mouse]
Enables leptin receptor activity. Involved in several processes, including glucose homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and respiratory system. Used to study metabolic dysfunction-associated steatotic liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lepr |
| Official Name | leptin receptor [Source:MGI Symbol;Acc:MGI:104993] |
| Ensembl ID | ENSMUSG00000057722 |
| Bio databases IDs | |
| Aliases | leptin receptor |
| Synonyms | CD295, db, diabetes, Fa, LEPROT, leptin receptor, LEPTIN receptor splice variant form 13.2, Modb1, obese-like, obl, OB-R, Ob-re, OB receptor, OB-RGRP, Ob-RM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lepr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ig-like C2-type domain
- extracellular domain
- Box motif
- immunoglobulin domain
- Obesity receptor immunoglobulin like domain
- protein binding
- Fibronectin type 3 domain
- identical protein binding
- polypeptide hormone binding
- phosphotyrosine motif
- YXXP domain
- cytokine receptor homology domain
- Box I domain
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- protein-hormone receptor
- STAT3 binding domain
- cytokine receptor
- transmembrane receptor
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Lepr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- insulin
- monocyte-derived macrophages
- N-ethylmaleimide
- tetradecanoylphorbol acetate
- beta-estradiol
- mir-21 (includes others)
- lipopolysaccharide
- IL33
- IUB288
- growth hormone
disease
- neoplasia
- ischemic stroke
- weight gain
- epithelial cancer
- epithelial neoplasia
- cancer
- digestive system cancer
- abdominal cancer
- adenoma formation
- benign neoplasia
phenotypes
- abnormal bone structure
- abnormal gait
- abnormal locomotor behavior
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating chloride level
- decreased exploration in new environment
- decreased heart weight
- decreased lean body mass
- decreased leukocyte cell number
- decreased lymphocyte cell number
- decreased spleen weight
- enlarged liver
- female infertility
- hypoactivity
- impaired righting response
- increased anxiety-related response
- increased circulating HDL cholesterol level
- increased circulating alanine transaminase level
- increased circulating alkaline phosphatase level
- increased circulating aspartate transaminase level
- increased circulating bilirubin level
- increased circulating calcium level
- increased circulating cholesterol level
- increased circulating fructosamine level
- increased circulating glucose level
- increased circulating iron level
- increased circulating phosphate level
- increased circulating potassium level
- increased circulating serum albumin level
- increased circulating total protein level
- increased exploration in new environment
- increased hematocrit
- increased hemoglobin content
- increased mean corpuscular volume
- increased mean platelet volume
- increased monocyte cell number
- increased total body fat amount
- limb grasping
- male infertility
- small seminal vesicle
- thrombocytopenia
- tremors
- trunk curl
- abnormal CD4-positive alpha beta T cell morphology
- abnormal CD8-positive alpha beta T cell morphology
- abnormal CNS synaptic transmission
- abnormal acute inflammation
- abnormal adipose tissue amount
- abnormal adipose tissue morphology
- abnormal adrenal gland zona reticularis morphology
- abnormal aerobic respiration
- abnormal axon extension
- abnormal axon morphology
- abnormal behavior
- abnormal blood circulation
- abnormal body temperature
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal cardiovascular system physiology
- abnormal chemokine level
- abnormal chemokine secretion
- abnormal circadian temperature homeostasis
- abnormal circulating HDL cholesterol level
- abnormal circulating alanine transaminase level
- abnormal circulating alkaline phosphatase level
- abnormal circulating aspartate transaminase level
- abnormal circulating bilirubin level
- abnormal circulating calcium level
- abnormal circulating chloride level
- abnormal circulating cholesterol level
- abnormal circulating fructosamine level
- abnormal circulating glucose level
- abnormal circulating insulin level
- abnormal circulating iron level
- abnormal circulating lipid level
- abnormal circulating phosphate level
- abnormal circulating potassium level
- abnormal circulating serum albumin level
- abnormal circulating total protein level
- abnormal conditioned taste aversion behavior
- abnormal diestrus
- abnormal digestive system physiology
- abnormal eating behavior
- abnormal endometrium morphology
- abnormal energy expenditure
- abnormal epididymal fat pad morphology
- abnormal estrous cycle
- abnormal exocrine pancreas morphology
- abnormal exploration in a new environment
- abnormal eye electrophysiology
- abnormal fat pad morphology
- abnormal female reproductive system morphology
- abnormal food intake
- abnormal functional residual capacity
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal heart weight
- abnormal hematocrit
- abnormal hemoglobin content
- abnormal hormone level
- abnormal hypothalamus physiology
- abnormal inhibitory postsynaptic currents
- abnormal insulin secretion
- abnormal interleukin level
- abnormal intestinal epithelium morphology
- abnormal intraocular pressure
- abnormal kidney calyx morphology
- abnormal kidney morphology
- abnormal kidney papilla morphology
- abnormal lactation
- abnormal lean body mass
- abnormal learning/memory/conditioning
- abnormal leukocyte morphology
- abnormal lipid level
- abnormal locomotor activation
- abnormal locomotor circadian rhythm
- abnormal lung compliance
- abnormal metestrus
- abnormal monocyte cell number
- abnormal myelin sheath morphology
- abnormal myocardial fiber morphology
- abnormal myocardium layer morphology
- abnormal nerve conduction
- abnormal nervous system morphology
- abnormal nucleotide metabolism
- abnormal osteoclast differentiation
- abnormal oxygen consumption
- abnormal pancreas physiology
- abnormal pancreatic beta cell morphology
- abnormal pancreatic beta cell physiology
- abnormal pancreatic islet morphology
- abnormal pelvic girdle bone morphology
- abnormal renal glomerulus morphology
- abnormal respiratory electron transport chain
- abnormal respiratory mechanics
- abnormal response/metabolism to endogenous compounds
- abnormal skeleton development
- abnormal spatial learning
- abnormal spatial reference memory
- abnormal spleen weight
- abnormal uterus morphology
- abnormal vascular development
- abnormal vascular wound healing
- abnormal white adipose tissue morphology
- absent adrenal medulla
- absent estrous cycle
- absent estrus
- absent long term depression
- adipose tissue inflammation
- albuminuria
- altered response to myocardial infarction
- anovulation
- cardiac ischemia
- constricted vagina orifice
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased T cell proliferation
- decreased body length
- decreased body temperature
- decreased body weight
- decreased carbon dioxide production
- decreased cardiac muscle contractility
- decreased cardiac output
- decreased cell death
- decreased circulating adiponectin level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating leptin level
- decreased circulating triglyceride level
- decreased corpora lutea number
- decreased follicle stimulating hormone level
- decreased gonadal fat pad weight
- decreased heart rate
- decreased insulin secretion
- decreased mature ovarian follicle number
- decreased motor neuron number
- decreased muscle weight
- decreased oocyte number
- decreased oxygen consumption
- decreased prostaglandin level
- decreased pulmonary ventilation
- decreased respiratory quotient
- decreased response to antigen
- decreased splenocyte number
- decreased systemic arterial blood pressure
- decreased systemic arterial systolic blood pressure
- decreased urine albumin level
- decreased uterus weight
- degranulated pancreatic beta cells
- delayed estrous cycle
- delayed wound healing
- enlarged adrenal glands
- enlarged placenta
- enlarged spleen
- expanded mesangial matrix
- extended life span
- glomerulosclerosis
- heart left ventricle hypertrophy
- hepatic steatosis
- hyperglycemia
- hyperlipidemia
- hypoglycemia
- impaired adaptive thermogenesis
- impaired balance
- impaired coordination
- impaired glucose tolerance
- improved glucose tolerance
- increased IgE level
- increased birth weight
- increased blood uric acid level
- increased body fat mass
- increased body length
- increased body size
- increased body weight
- increased bone volume
- increased brown adipose tissue amount
- increased cholesterol level
- increased circulating LDL cholesterol level
- increased circulating VLDL cholesterol level
- increased circulating corticosterone level
- increased circulating free fatty acid level
- increased circulating glucagon level
- increased circulating insulin level
- increased circulating interleukin-6 level
- increased circulating ketone body level
- increased circulating leptin level
- increased circulating triglyceride level
- increased creatinine clearance
- increased effector memory CD4-positive alpha-beta T cell number
- increased effector memory CD8-positive alpha-beta T cell number
- increased enterocyte apoptosis
- increased food intake
- increased glucagon secretion
- increased glycosylated hemoglobin level
- increased hepatocyte apoptosis
- increased insulin secretion
- increased insulin sensitivity
- increased interleukin-6 secretion
- increased kidney weight
- increased left ventricle diastolic pressure
- increased liver glycogen level
- increased liver triglyceride level
- increased liver weight
- increased mean systemic arterial blood pressure
- increased mesenteric fat pad weight
- increased metastatic potential
- increased neutrophil cell number
- increased omental fat pad weight
- increased oxygen consumption
- increased pancreatic alpha cell number
- increased pancreatic beta cell mass
- increased pancreatic beta cell number
- increased pancreatic islet cell apoptosis
- increased percent body fat/body weight
- increased sensitivity to induced morbidity/mortality
- increased susceptibility to age related obesity
- increased susceptibility to autoimmune diabetes
- increased susceptibility to diet-induced obesity
- increased susceptibility to endotoxin shock
- increased susceptibility to non-insulin-dependent diabetes
- increased susceptibility to parasitic infection
- increased susceptibility to weight gain
- increased urine glucose level
- increased urine protein level
- increased vasoconstriction
- infertility
- insulin resistance
- liver fibrosis
- liver inflammation
- lung inflammation
- macrovesicular hepatic steatosis
- maternal effect
- microvesicular hepatic steatosis
- no abnormal phenotype detected
- obese
- pancreas inflammation
- pancreatic islet hyperplasia
- periinsulitis
- polydipsia
- polyphagia
- polyuria
- premature death
- reduced female fertility
- reduced long term potentiation
- reduced male fertility
- reduced male mating frequency
- renal glomerular immunoglobulin deposits
- renal glomerular protein deposits
- short femur
- short tail
- short tibia
- small male preputial glands
- small uterus
- weight loss
role in cell
- apoptosis
- activation in
- phosphorylation in
- expression in
- proliferation
- migration
- loss in
- quantity
- transcription in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- perinuclear region
- intracellular membranes
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- cytosol
- apical cell surfaces
- trans Golgi network
- early endosomes
- extracellular matrix
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lepr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- leptin-mediated signaling pathway
- multicellular organismal development
- energy reserve metabolic process
- cholesterol metabolic process
- response to leptin stimulus
- negative regulation of gluconeogenesis
- cell surface receptor signaling pathway
- regulation of feeding behavior
- T cell differentiation
- regulation of transport
- glycogen metabolic process
- angiogenesis
- regulation of bone remodeling
- cytokine-mediated signaling pathway
- negative regulation of autophagy
- glucose homeostasis
- positive regulation of protein phosphorylation
- energy homeostasis
- phagocytosis
- glial cell proliferation
- sexual reproduction
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- extracellular region
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- leptin receptor activity
- cytokine receptor activity
- cytokine binding