GADD45B
GADD45B Gene Summary
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | GADD45B |
| Official Name | growth arrest and DNA damage inducible beta [Source:HGNC Symbol;Acc:HGNC:4096] |
| Ensembl ID | ENSG00000099860 |
| Bio databases IDs | |
| Aliases | growth arrest and DNA damage inducible beta, myeloid differentiation primary response, growth arrest and DNA-damage-inducible beta |
| Synonyms | GADD45beta,Gadd45β,growth arrest and DNA-damage-inducible 45 beta,growth arrest and DNA-damage-inducible 45 β,growth arrest and DNA damage inducible beta,growth arrest and DNA-damage-inducible, beta,growth arrest and DNA damage inducible β,growth arrest and DNA-damage-inducible, β,MYD118,Myeloid differentiation primary response |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- protein binding
Pathways
Biological processes and signaling networks where the GADD45B gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MYC
- MAP2K7
- CNOT6
- MAP3K4
- CNOT6L
- PAK
- GADD45A
- PCNA
- GADD45GIP1
- CFTR
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- lung adenocarcinoma
- non-small cell lung cancer
- COVID-19
regulated by
- ibrutinib
- CTNNB1
- lipopolysaccharide
- glutamine
- hydrogen peroxide
- TNF
- tetrachlorodibenzodioxin
- SMAD3
- RBM47
- TGFB1
regulates
- NFkB (complex)
- IL2
- IL6
- CDKN1A
- TP53
- BCL2
- CASP3
- BCL2L1
- JUND
- Cyp2b13/Cyp2b9
role in cell
- growth
- expression in
- binding in
- cell death
- production in
- activation in
- phosphorylation in
- proliferation
- apoptosis
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GADD45B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
- apoptotic process
- positive regulation of apoptotic process
- cell differentiation
- regulation of cell cycle
- positive regulation of p38MAPK cascade
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding