Hoxa2 Gene Summary [Mouse]
This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | Hoxa2 |
| Official Name | homeobox A2 [Source:MGI Symbol;Acc:MGI:96174] |
| Ensembl ID | ENSMUSG00000014704 |
| Bio databases IDs | |
| Aliases | homeobox A2 |
| Synonyms | homeobox A2, HOX1.11, HOX1K, Hoxa11, Hoxa2l, LOC100911443, MCOHI, NEWGENE 2813, RATHOX111A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microtia, hearing impairment, and cleft palate
- respiratory failure
- severe acute respiratory syndrome
- meteorism
- palatal shelves fail to meet at midline
- microtia
- preeclampsia
- aphagia
phenotypes
- abnormal auditory brainstem response
- abnormal gait
- abnormal snout morphology
- decreased cardiac output
- decreased cardiac stroke volume
- decreased food intake
- decreased prepulse inhibition
- decreased respiratory quotient
- preweaning lethality complete penetrance
- abnormal Meckel's cartilage morphology
- abnormal basioccipital bone morphology
- abnormal basisphenoid bone morphology
- abnormal behavior
- abnormal brain development
- abnormal cartilage development
- abnormal circulating alkaline phosphatase level
- abnormal craniofacial bone morphology
- abnormal craniofacial morphology
- abnormal cranium morphology
- abnormal ear morphology
- abnormal external auditory canal morphology
- abnormal facial motor nucleus morphology
- abnormal facial nerve morphology
- abnormal food intake
- abnormal glossopharyngeal nerve morphology
- abnormal gonial bone morphology
- abnormal hyoid bone lesser horn morphology
- abnormal hyoid bone morphology
- abnormal incudostapedial joint morphology
- abnormal incus morphology
- abnormal malleus morphology
- abnormal middle ear ossicle morphology
- abnormal nervous system morphology
- abnormal neuron differentiation
- abnormal otic capsule morphology
- abnormal outer ear morphology
- abnormal prepulse inhibition
- abnormal respiratory quotient
- abnormal retrotympanic process morphology
- abnormal rhombomere 2 morphology
- abnormal rhombomere 3 morphology
- abnormal rhombomere boundary morphology
- abnormal rhombomere morphology
- abnormal scala vestibuli morphology
- abnormal skeleton development
- abnormal skeleton morphology
- abnormal stapedial artery morphology
- abnormal stapes morphology
- abnormal styloglossus muscle morphology
- abnormal styloid process morphology
- abnormal suckling behavior
- abnormal temporal bone morphology
- abnormal temporal bone squamous part morphology
- abnormal temporal bone tympanic part morphology
- abnormal tensor tympani muscle morphology
- abnormal tongue muscle morphology
- abnormal tubotympanic recess morphology
- abnormal tympanic cavity morphology
- abnormal tympanic membrane morphology
- abnormal tympanic ring morphology
- abnormal vagus nerve morphology
- absent hyoid bone lesser horns
- absent malleus processus brevis
- absent outer ear
- absent stapedial artery
- absent stapedius muscle
- absent stapes
- absent stylohyoid muscle
- absent styloid process
- aphagia
- bifid tongue
- cleft palate
- cleft secondary palate
- decreased rhombomere 3 size
- decreased sensory neuron number
- enlarged gonial bone
- increased oligodendrocyte progenitor number
- increased rhombomere 1 size
- lethality at weaning complete penetrance
- meteorism
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- postnatal growth retardation
- small malleus processus brevis
role in cell
- activation in
- differentiation
- response by
- development
- ubiquitination in
- polyubiquitination in
- stabilization in
- commitment
- degradation in
- fate determination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- motor axon guidance
- rhombomere 3 morphogenesis
- brain segmentation
- anterior/posterior pattern specification
- negative regulation of neuron differentiation
- middle ear morphogenesis
- rhombomere 2 development
- osteoblast development
- positive regulation of transcription from RNA polymerase II promoter
- pharyngeal system development
- segment specification
- embryonic viscerocranium morphogenesis
- dorsal/ventral pattern formation
- negative regulation of osteoblast differentiation
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to retinoic acid
- muscle structure development
- cell fate determination
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity