Tle6 Gene Summary [Mouse]
Predicted to enable transcription corepressor activity. Involved in several processes, including cytoskeleton organization; positive regulation of embryonic development; and spermatogonial cell division. Acts upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Located in cell cortex and nucleus. Part of subcortical maternal complex. Is expressed in brain; early conceptus; foregut-midgut junction; and genitourinary system. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tle6 |
| Official Name | transducin-like enhancer of split 6 [Source:MGI Symbol;Acc:MGI:2149593] |
| Ensembl ID | ENSMUSG00000034758 |
| Bio databases IDs | |
| Aliases | transducin-like enhancer of split 6 |
| Synonyms | 1810057E06Rik, FLJ14009, GRG6, MGC14966, OZEMA15, PREMBL, RGD1561530, TLE family member 6, subcortical maternal complex member, transducin-like enhancer of split 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tle6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40
- protein binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- preimplantation embryonic lethality 1
- acute myeloid leukemia
- female infertility with embryonic developmental arrest
role in cell
- proliferation
- migration
- differentiation
- abnormal morphology
- tumorigenicity
- organization
- transactivation in
- cell division
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- organelle
- Cytoplasm
- cell cortex
- cytosol
- sperm midpiece
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tle6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- endoplasmic reticulum localization
- establishment of spindle localization
- actin filament organization
- embryonic process involved in female pregnancy
- mitochondrion localization
- positive regulation of embryonic development
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cell cortex
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity