Sfn Gene Summary [Mouse]
Enables phosphoprotein binding activity and protein kinase binding activity. Involved in several processes, including cAMP/PKA signal transduction; establishment of skin barrier; and protein export from nucleus. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of cell population proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sfn |
| Official Name | stratifin [Source:MGI Symbol;Acc:MGI:1891831] |
| Ensembl ID | ENSMUSG00000047281 |
| Bio databases IDs | |
| Aliases | stratifin |
| Synonyms | 14-3-3, 14-3-3 Sigma, 14-3-3 σ, ER, HME1, Mme1, Stratifin, YWHAS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sfn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- protein kinase binding
- 14-3-3 domain
- phosphoprotein binding
- 14-3-3 protein
- protein binding
- protein kinase c inhibitor
- identical protein binding
- phosphoprotein amino acid binding
Pathways
Biological processes and signaling networks where the Sfn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- prostate cancer
- organismal death
- preeclampsia
- asthma
- lung adenocarcinoma formation
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
phenotypes
- abnormal B cell differentiation
- abnormal apical ectodermal ridge morphology
- abnormal axial skeleton morphology
- abnormal craniofacial development
- abnormal embryonic autopod plate morphology
- abnormal epidermal layer morphology
- abnormal epidermis stratum basale morphology
- abnormal epidermis stratum corneum morphology
- abnormal epidermis stratum granulosum morphology
- abnormal epidermis stratum spinosum morphology
- abnormal external auditory canal morphology
- abnormal eyelid aperture
- abnormal eyelid fusion
- abnormal eyelid morphology
- abnormal head morphology
- abnormal jaw morphology
- abnormal keratinocyte differentiation
- abnormal limb bud morphology
- abnormal limb development
- abnormal liver morphology
- abnormal mammary gland epithelium morphology
- abnormal mandible morphology
- abnormal nasal cavity morphology
- abnormal nasopharynx morphology
- abnormal oral cavity morphology
- abnormal oral epithelium morphology
- abnormal perineum morphology
- abnormal phalanx morphology
- abnormal pharynx morphology
- abnormal radius morphology
- abnormal spine curvature
- abnormal spleen B cell follicle morphology
- abnormal spleen morphology
- abnormal tail morphology
- abnormal tongue morphology
- absent epidermis stratum corneum
- absent epidermis stratum granulosum
- absent spleen marginal zone
- anal atresia
- brachyphalangia
- cleft secondary palate
- decreased B cell number
- decreased B-1a cell number
- decreased IgG level
- decreased IgM level
- decreased caudal vertebrae number
- decreased follicular B cell number
- decreased hair follicle number
- decreased marginal zone B cell number
- distorted hair follicle pattern
- epidermal hyperplasia
- flat face
- flattened snout
- fused lips
- herniated intestine
- impaired skin barrier function
- increased B cell apoptosis
- increased B cell proliferation
- increased skin papilloma incidence
- increased squamous cell carcinoma incidence
- increased susceptibility to Riboviria infection
- increased susceptibility to Riboviria infection induced morbidity/mortality
- kinked tail
- kyphosis
- lethality at weaning incomplete penetrance
- microcephaly
- microphthalmia
- neonatal lethality complete penetrance
- oral atresia
- palatal shelf fusion with tongue or mandible
- perinatal lethality complete penetrance
- postnatal growth retardation
- premature hair loss
- respiratory distress
- respiratory failure
- shiny skin
- short limbs
- short snout
- short tail
- small ears
- small external nares
- small limb buds
- sparse hair
- syndactyly
- thick epidermis
- thin epidermis
- thin lip
- thin skin
role in cell
- expression in
- invasion by
- migration
- proliferation
- apoptosis
- upregulation in
- growth
- cell death
- colony formation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Extracellular Space
- perinuclear region
- Nucleus
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sfn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of epidermal cell division
- keratinocyte proliferation
- positive regulation of protein export from nucleus
- positive regulation of epidermal cell differentiation
- signal transduction
- protein localization
- DNA damage response, signal transduction resulting in induction of apoptosis
- protein export from nucleus
- negative regulation of innate immune response
- negative regulation of protein kinase activity
- establishment of skin barrier
- keratinocyte development
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of keratinocyte proliferation
- positive regulation of cell growth
- negative regulation of stem cell proliferation
- stem cell proliferation
- protein kinase A signaling cascade
- release of cytochrome c from mitochondria
- regulation of cell cycle
- keratinization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- cadherin binding
- phosphoserine binding
- protein kinase C inhibitor activity