Kras Gene Summary [Mouse]
Enables GTPase activity and protein-membrane adaptor activity. Acts upstream of or within several processes, including Ras protein signal transduction; forebrain astrocyte development; and modulation of chemical synaptic transmission. Located in membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study several diseases, including Noonan syndrome 3; arteriovenous malformations of the brain; gastrointestinal system cancer (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kras |
| Official Name | Kirsten rat sarcoma viral oncogene homolog [Source:MGI Symbol;Acc:MGI:96680] |
| Ensembl ID | ENSMUSG00000030265 |
| Bio databases IDs | |
| Aliases | Kirsten rat sarcoma viral oncogene homolog |
| Synonyms | AI929937, CFC2, c-Ki-ras, c-Ki-ras2, c-Ki-ras p21, C-K-RAS, KI-RAS, KI-RAS4B, Kirsten rat sarcoma viral oncogene homolog, KRAS1, KRAS2, K-RAS2A, K-RAS2B, K-RAS B, KRAS proto-oncogene, GTPase, NS, NS3, OES, p21, p21B, p21ras, RALD, RAS, RASK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kras often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphate binding domain
- membrane-association domain
- Ras family
- protein binding activity, bridging
- enzyme
- identical protein binding
- effector domain
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- membrane targeting signal
- farnesylation site
- GTP binding domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- LRR-domain binding
- GTPase
- protein binding
- Ras subfamily of RAS small GTPases
- kinase
- GMP binding
- polybasic membrane localization signal
- binding protein
- CAAX box
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- hypervariable region
Pathways
Biological processes and signaling networks where the Kras gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- Adrenomedullin signaling pathway
- Agrin Interactions at Neuromuscular Junction
- Aldosterone Signaling in Epithelial Cells
- Angiopoietin Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apoptosis Signaling
- Axonal Guidance Signaling
- B Cell Receptor Signaling
- Bladder Cancer Signaling
- BMP signaling pathway
- Breast Cancer Regulation by Stathmin1
- Cancer Drug Resistance By Drug Efflux
- Cardiac Hypertrophy Signaling
- CCR3 Signaling in Eosinophils
- CXCR4 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic rectal cancer
- lymphoma
- colorectal cancer
- neoplasia
- non-Hodgkin disease
- adenoma
- rheumatoid arthritis
- epithelial cancer
- epithelial neoplasia
- cancer
phenotypes
- abnormal bone marrow cell physiology
- abnormal brain development
- abnormal bronchus morphology
- abnormal common lymphocyte progenitor cell morphology
- abnormal common myeloid progenitor cell morphology
- abnormal cranium morphology
- abnormal definitive hematopoiesis
- abnormal ear position
- abnormal embryonic neuroepithelium morphology
- abnormal facial morphology
- abnormal fetal cardiomyocyte proliferation
- abnormal heart morphology
- abnormal hematopoietic system morphology/development
- abnormal kidney morphology
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal myocardial fiber physiology
- abnormal systemic arterial blood pressure
- anemia
- cardiac fibrosis
- cellular necrosis
- decreased CD8-positive alpha-beta T cell number
- decreased body length
- decreased body size
- decreased cardiac muscle contractility
- decreased cranium length
- decreased embryo size
- decreased lung tumor incidence
- dilated cardiomyopathy
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality complete penetrance
- enlarged heart
- enlarged myocardial fiber
- enlarged spleen
- extramedullary hematopoiesis
- fetal growth retardation
- flattened snout
- heart hyperplasia
- hypertension
- increased T cell derived lymphoma incidence
- increased apoptosis
- increased basophil cell number
- increased carcinoma incidence
- increased cardiac muscle contractility
- increased cardiac output
- increased cell proliferation
- increased cranium height
- increased cranium width
- increased embryonic neuroepithelium apoptosis
- increased eosinophil cell number
- increased fibrosarcoma incidence
- increased granulocyte monocyte progenitor cell number
- increased hemangiosarcoma incidence
- increased hematopoietic stem cell number
- increased leukocyte cell number
- increased lung adenocarcinoma incidence
- increased lung adenoma incidence
- increased lung tumor incidence
- increased lymphoma incidence
- increased mesothelioma incidence
- increased myeloid cell number
- increased myocardial fiber number
- increased neuron apoptosis
- increased neutrophil cell number
- increased papilloma incidence
- increased sarcoma incidence
- increased skin papilloma incidence
- increased squamous cell carcinoma incidence
- increased systemic arterial diastolic blood pressure
- increased systemic arterial systolic blood pressure
- increased tumor incidence
- liver hypoplasia
- no abnormal phenotype detected
- ocular hypertelorism
- pale liver
- pallor
- pericardial edema
- perinatal lethality complete penetrance
- perinatal lethality incomplete penetrance
- premature death
- prenatal lethality complete penetrance
- slow postnatal weight gain
- small heart
- small liver
- spleen vascular congestion
- thick aortic valve
- thin myocardium
- thin ventricular wall
- thrombocytopenia
- triangular face
role in cell
- epithelial-mesenchymal transition
- damage in
- number
- production in
- synthesis in
- survival
- expression in
- phosphorylation in
- differentiation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- membrane fraction
- perinuclear region
- cellular membrane
- Plasma Membrane
- Mitochondria
- cytosol
- cytoplasmic face of plasma membrane
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondrial outer membrane
- endosomal membrane
- perinuclear space
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kras gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rac protein signal transduction
- Rac protein signal transduction
- epithelial tube branching involved in lung morphogenesis
- positive regulation of glial cell proliferation
- forebrain astrocyte development
- visual learning
- Ras protein signal transduction
- negative regulation of neuron apoptotic process
- MAPK cascade
- negative regulation of epithelial cell differentiation
- striated muscle cell differentiation
- skeletal muscle cell differentiation
- regulation of long-term neuronal synaptic plasticity
- homeostasis of number of cells within a tissue
- positive regulation of gene expression
- Type I pneumocyte differentiation
- positive regulation of protein phosphorylation
- gene expression
- glial cell proliferation
- regulation of synaptic transmission, GABAergic
- actin cytoskeleton organization
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- focal adhesion
- cytoplasm
- membrane
- cytosol
- Golgi membrane
- mitochondrial outer membrane
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- protein anchor
- GTPase activity
- small monomeric GTPase activity
- GDP binding