Slc19a1 Gene Summary [Mouse]
Enables folic acid transmembrane transporter activity and methotrexate transmembrane transporter activity. Involved in folate import across plasma membrane and methotrexate transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cleft lip; dextro-looped transposition of the great arteries; immunodeficiency 114; and malaria. Orthologous to human SLC19A1 (solute carrier family 19 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc19a1 |
| Official Name | solute carrier family 19 (folate transporter), member 1 [Source:MGI Symbol;Acc:MGI:103182] |
| Ensembl ID | ENSMUSG00000001436 |
| Bio databases IDs | |
| Aliases | solute carrier family 19 (folate transporter), member 1 |
| Synonyms | CHMD, FOLT, hRFC, hSLC19A1, IFC-1, IMD114, LOC101928717, MEGAF, MTX-1, REFC, RFC, RFC-1, RFT-1, solute carrier family 19 (folate transporter), member 1, solute carrier family 19 member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc19a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclic nucleotide binding
- nucleotide binding
- folic acid binding
- Major Facilitator Superfamily
- protein binding
- RFC reduced folate carrier
- organic anion transporter
- purine nucleotide binding
- purine nucleotide transporter
- purine ribonucleotide transporter
- methotrexate transporter
- reduced folate carrier
- adenine nucleotide transporter
- binding protein
- xenobiotic transporter
- transmembrane domain
- adenyl nucleotide binding
- antiporter
- guanyl nucleotide binding
- folate transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc19a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- arthritis
- lung cancer
- organismal death
- growth failure
- atrioventricular septal defect
- acute lymphoblastic leukemia
- folate-responsive immunodeficiency 114
- drug toxicity
- folate-responsive megaloblastic anemia
role in cell
- activation in
- expression in
- accumulation in
- phosphorylation in
- proliferation
- growth
- cell viability
- number
- binding
- contact growth inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- vesicles
- microsome
- apical membrane
- basolateral membrane
- mitochondrial membrane
- brush border
- membrane processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc19a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- folic acid transport
- drug transmembrane transport
- methotrexate transport
- folic acid metabolic process
- female pregnancy
- organic anion transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- reduced folate carrier activity
- folic acid transporter activity
- antiporter activity
- methotrexate transporter activity
- organic anion transmembrane transporter activity
- folic acid binding