Ccl2 Gene Summary [Mouse]
This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ccl2 |
| Official Name | chemokine (C-C motif) ligand 2 [Source:MGI Symbol;Acc:MGI:98259] |
| Ensembl ID | ENSMUSG00000035385 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) ligand 2 |
| Synonyms | AI323594, Ccl13, C-C motif chemokine ligand 2, CHEMOKINE C-C MOTIF LIGAND 2, GDCF-2, HC11, HSMCR30, JE, JE/CCL2, Macrophage Chemotactic Factor, MCAF, MCP-1, MCP1a, PDGF-inducible, SCYA2, Sigje, SMC-CF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- chemokine receptor binding domain
- chemoattractant
- Small cytokines (intecrine/chemokine), interleukin-8 like
- G-protein-coupled receptor binding
- protein binding
- receptor binding
- cytokine
- heparin binding
Pathways
Biological processes and signaling networks where the Ccl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Inflammation in Asthma
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Apelin Endothelial Signaling Pathway
- Atherosclerosis Signaling
- Chemokine Signaling
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-17 Signaling
- IL-17A Signaling in Fibroblasts
- LXR/RXR Activation
- MSP-RON Signaling Pathway
- Neuroinflammation Signaling Pathway
- Renin-Angiotensin Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17A in Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- verlukast
- metformin
- parthenolide
- erlotinib
- quercetin
- heavy metal
- SOD
- dextran sulfate
- tyrphostin AG 1478
- 11,12-epoxyeicosatrienoic acid
disease
- tuberculosis
- cancer
- diabetes mellitus
- pulmonary hypertension
- Duchenne muscular dystrophy
- epithelial cancer
- epithelial neoplasia
- digestive system cancer
- adenoma formation
- hyperplasia
phenotypes
- abnormal Bruch membrane morphology
- abnormal T cell physiology
- abnormal blood circulation
- abnormal chemokine level
- abnormal chemokine secretion
- abnormal choriocapillaris morphology
- abnormal conditioned taste aversion behavior
- abnormal cytokine secretion
- abnormal dendritic cell chemotaxis
- abnormal dendritic cell physiology
- abnormal epididymal fat pad morphology
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal gonadal fat pad morphology
- abnormal heart left ventricle morphology
- abnormal macrophage chemotaxis
- abnormal macrophage physiology
- abnormal microglial cell physiology
- abnormal monocyte morphology
- abnormal neutrophil physiology
- abnormal optic choroid morphology
- abnormal physiological neovascularization
- abnormal posture
- abnormal response to injury
- abnormal retinal pigment epithelium morphology
- abnormal skeletal muscle morphology
- abnormal skeletal muscle regeneration
- alcohol aversion
- alcohol preference
- altered response to myocardial infarction
- choroidal neovascularization
- decreased adiponectin level
- decreased alcohol consumption
- decreased angiogenesis
- decreased body weight
- decreased circulating free fatty acid level
- decreased circulating insulin level
- decreased dendritic cell number
- decreased fat cell size
- decreased incidence of tumors by chemical induction
- decreased inflammatory response
- decreased interferon-gamma secretion
- decreased interleukin-1 beta secretion
- decreased interleukin-12b secretion
- decreased interleukin-4 secretion
- decreased interleukin-5 secretion
- decreased leukocyte cell number
- decreased lymphocyte cell number
- decreased macrophage cell number
- decreased physiological sensitivity to xenobiotic
- decreased sensitivity to xenobiotic induced morbidity/mortality
- decreased susceptibility to experimental autoimmune encephalomyelitis
- decreased susceptibility to hepatic steatosis
- decreased susceptibility to induced colitis
- decreased susceptibility to neuronal excitotoxicity
- decreased susceptibility to type IV hypersensitivity reaction
- delayed wound healing
- impaired glucose tolerance
- impaired macrophage chemotaxis
- impaired righting response
- improved glucose tolerance
- increased CD4-positive alpha beta T cell number
- increased IgG level
- increased IgG1 level
- increased adiponectin level
- increased alcohol consumption
- increased circulating glucose level
- increased circulating insulin level
- increased circulating interferon-gamma level
- increased circulating interleukin-10 level
- increased circulating leptin level
- increased circulating tumor necrosis factor level
- increased fluid intake
- increased insulin sensitivity
- increased interleukin-10 secretion
- increased muscle weight
- increased neutrophil cell number
- increased osteoclast cell number
- increased percent body fat/body weight
- increased susceptibility to diet-induced obesity
- increased susceptibility to infection induced morbidity/mortality
- increased susceptibility to parasitic infection
- increased total fat pad weight
- increased vasodilation
- lipofuscinosis
- no abnormal phenotype detected
- premature tooth eruption
- retinal degeneration
- retinal deposits
- retinal outer nuclear layer degeneration
- retinal photoreceptor degeneration
- skeletal muscle necrosis
role in cell
- phosphorylation in
- expression in
- invasion by
- migration
- proliferation
- apoptosis
- upregulation in
- growth
- cell death
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- granules
- MHC class II compartments
- Golgi stacks
- trans Golgi network
- endocytotic vesicle
- secretory granules
- perikaryon
- axons
- dendrites
- axon terminals
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- helper T cell extravasation
- cytoskeleton organization
- negative regulation of glial cell apoptotic process
- cell adhesion
- protein phosphorylation
- positive regulation of GTPase activity
- negative regulation of neuron apoptotic process
- JAK-STAT cascade
- chemotaxis
- positive regulation of T cell activation
- inflammatory response
- angiogenesis
- macrophage chemotaxis
- cytokine-mediated signaling pathway
- eosinophil chemotaxis
- humoral immune response
- negative regulation of G1/S transition of mitotic cell cycle
- positive regulation of endothelial cell apoptotic process
- cellular response to tumor necrosis factor
- positive regulation of synaptic transmission, glutamatergic
- astrocyte cell migration
- cellular homeostasis
- G-protein coupled receptor signaling pathway
- signal transduction
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- cellular response to fibroblast growth factor stimulus
- cell surface receptor signaling pathway
- positive regulation of calcium ion import
- organ morphogenesis
- response to bacterium
- positive regulation of apoptotic cell clearance
- positive regulation of nitric-oxide synthase biosynthetic process
- cellular response to lipopolysaccharide
- monocyte chemotaxis
- chemokine-mediated signaling pathway
- cellular response to interleukin-1
- viral genome replication
- sensory perception of pain
- negative regulation of natural killer cell chemotaxis
- cellular response to interferon-gamma
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- CCR chemokine receptor binding
- CCR2 chemokine receptor binding
- protein kinase activity
- chemokine activity
- receptor binding