Adamts3 Gene Summary [Mouse]
Enables peptidase activity. Acts upstream of or within in utero embryonic development and protein processing. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Is expressed in embryo; footplate apical ectodermal ridge; and handplate apical ectodermal ridge. Human ortholog(s) of this gene implicated in Hennekam syndrome. Orthologous to human ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts3 |
| Official Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 [Source:MGI Symbol;Acc:MGI:3045353] |
| Ensembl ID | ENSMUSG00000043635 |
| Bio databases IDs | |
| Aliases | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 |
| Synonyms | 1100001H14RIK, 6330442E02, 6330442E02Rik, ADAM metallopeptidase with thrombospondin type 1 motif 3, ADAM metallopeptidase with thrombospondin type 1, motif 3, ADAMTS-4, HKLLS3, KIAA0366 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adamts3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- thrombospondin-1 motif
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- PLAC (protease and lacunin) domain
- protein binding
- ADAM-TS Spacer 1
- ZnMc
- endopeptidase
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- coronary artery disease
- osteoarthritis
- hereditary disorder
- Hennekam lymphangiectasia-lymphedema syndrome type 3
- dental caries
- COVID-19
- Dupuytren contracture
- carcinoma in situ
- epithelial cancer in situ
role in cell
- apoptosis
- branching
- abnormal morphology
- organization
- elongation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adamts3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of vascular endothelial growth factor signaling pathway
- in utero embryonic development
- proteolysis
- extracellular matrix organization
- collagen catabolic process
- protein processing
- collagen fibril organization
- collagen biosynthetic process
- vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- endopeptidase activity
- heparin binding
- metalloendopeptidase activity