CALCR Gene Summary [Human]
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | CALCR |
| Official Name | calcitonin receptor [Source:HGNC Symbol;Acc:HGNC:1440] |
| Ensembl ID | ENSG00000004948 |
| Bio databases IDs | |
| Aliases | calcitonin receptor |
| Synonyms | calcitonin receptor, Clr, CRT, CT-R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CALCR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- G-protein coupled peptide receptor
- 7 transmembrane receptor (Secretin family)
- calcitonin gene-related polypeptide receptor
- intracellular loop
- cytoplasmic domain
- protein binding
- beta-amyloid binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- calcitonin receptor
Pathways
Biological processes and signaling networks where the CALCR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- postmenopausal osteoporosis
- hypercalcemia
- osteoporotic fracture
- hypoglycemia
- primary hyperparathyroidism
- Paget disease of bone
- insulin-dependent diabetes mellitus
- hypothyroidism
- plasma cell myeloma
role in cell
- apoptosis
- phosphorylation in
- activation in
- accumulation in
- cell death
- growth
- acidification
- differentiation
- signaling in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- acrosome
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CALCR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- regulation of mRNA stability
- cross-receptor inhibition within G-protein coupled receptor heterodimer
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- positive regulation of calcium-mediated signaling
- osteoclast differentiation
- positive regulation of protein kinase A signaling cascade
- ossification
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- response to glucocorticoid stimulus
- negative regulation of ossification
- activation of adenylate cyclase activity
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
- cilium
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcitonin gene-related polypeptide receptor activity
- calcitonin receptor activity
- beta-amyloid binding
- calcitonin binding