ZFX Gene Summary [Human]
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
Details
| Type | Processed Transcript |
| Official Symbol | ZFX |
| Official Name | zinc finger protein X-linked [Source:HGNC Symbol;Acc:HGNC:12869] |
| Ensembl ID | ENSG00000005889 |
| Bio databases IDs | |
| Aliases | zinc finger protein X-linked |
| Synonyms | MRXS37, RGD1562664, ZFX5, Zfx5,6, ZFX6, zinc finger protein X-linked, ZNF926, ZNF X-LINKED |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zfx / Zfy transcription activation region
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- X-linked syndromic intellectual developmental disorder type 37
- basal cell skin cancer
- skin neoplasia
- skin cancer
- Hutchinson-Gilford progeria syndrome
- oligozoospermia
- Turner syndrome
role in cell
- growth
- expression in
- quantity
- number
- binding in
- development
- transactivation in
- imatinib resistance
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- oocyte development
- homeostasis of number of cells
- spermatogenesis
- post-embryonic development
- fertilization
- parental behavior
- positive regulation of transcription from RNA polymerase II promoter
- ovarian follicle development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin insulator sequence binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription