Zfx Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Acts upstream of or within several processes, including oocyte development; ovarian follicle development; and parental behavior. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be active in chromosome. Is expressed in several structures, including 4-cell stage embryo; central nervous system; genitourinary system; ileum; and spleen. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfx |
| Official Name | zinc finger protein X-linked [Source:MGI Symbol;Acc:MGI:99211] |
| Ensembl ID | ENSMUSG00000079509 |
| Bio databases IDs | |
| Aliases | zinc finger protein X-linked |
| Synonyms | MRXS37, RGD1562664, ZFX5, Zfx5,6, ZFX6, zinc finger protein X-linked, ZNF926, ZNF X-LINKED |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zfx / Zfy transcription activation region
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- X-linked syndromic intellectual developmental disorder type 37
- basal cell skin cancer
- skin neoplasia
- skin cancer
- Hutchinson-Gilford progeria syndrome
- oligozoospermia
- Turner syndrome
role in cell
- growth
- expression in
- quantity
- number
- binding in
- development
- transactivation in
- imatinib resistance
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- oocyte development
- homeostasis of number of cells
- spermatogenesis
- post-embryonic development
- fertilization
- parental behavior
- positive regulation of transcription from RNA polymerase II promoter
- ovarian follicle development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin insulator sequence binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription