CDC23 Gene Summary [Human]
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC23 |
| Official Name | cell division cycle 23 [Source:HGNC Symbol;Acc:HGNC:1724] |
| Ensembl ID | ENSG00000094880 |
| Bio databases IDs | |
| Aliases | cell division cycle 23, anaphase promoting complex subunit 8 |
| Synonyms | 6030435O18, ANAPC8, APC8, CDC23 cell division cycle 23, cell division cycle 23, CUT23, D18Ertd243e, Rabkinesin6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- Tetratricopeptide repeats
- ubiquitin-protein transferase activity
- enzyme
- protein binding
- Anaphase promoting complex subunit 8 / Cdc23
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the CDC23 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung cancer
- systemic sclerosis
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
role in cell
- quantity
- expression in
- degradation in
- mitosis
- extrusion
- misalignment
- chromosomal congression
- cell cycle progression
- misalignment in
- aneuploidization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear scaffolds
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- regulation of exit from mitosis
- positive regulation of mitotic metaphase/anaphase transition
- regulation of mitotic cell cycle
- mitotic cell cycle
- ubiquitin-dependent protein catabolic process
- cell division
- regulation of meiotic cell cycle
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- mitotic metaphase plate congression
- mitotic metaphase/anaphase transition
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- anaphase-promoting complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding