CHAF1B Gene Summary [Human]
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CHAF1B |
| Official Name | chromatin assembly factor 1 subunit B [Source:HGNC Symbol;Acc:HGNC:1911] |
| Ensembl ID | ENSG00000159259 |
| Bio databases IDs | |
| Aliases | chromatin assembly factor 1 subunit B, M-phase phosphoprotein 7, Chromatin assembly factor I, p60 subunit, human chromatin assembly factor-I p60 subunit |
| Synonyms | 2600017H24Rik, CAF-1, CAF1A, CAF1P60, CAF-1 subunit B, CAF-I 60 kDa subunit, CAF-IP60, chromatin assembly factor 1 subunit B, chromatin assembly factor 1, subunit B, LOC102724630, MPHOSPH7, MPP7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHAF1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- Chromatin assembly factor complex 1 subunit p60, C-terminal
- WD40 repeats
- WD domain, G-beta repeat
- chromatin binding
- protein binding
Pathways
Biological processes and signaling networks where the CHAF1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
- Huntington disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- chromosomal instability
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- organismal death
role in cell
- number
- assembly
- replication in
- enrichment in
- derepression in
- transdifferentiation
- frequency
- cellular reprogramming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- DNA replication foci
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHAF1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- nucleosome assembly
- DNA replication-dependent nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- CAF-1 complex
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- unfolded protein binding
- chromatin binding