CD22 Gene Summary [Human]
Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CD22 |
| Official Name | CD22 molecule [Source:HGNC Symbol;Acc:HGNC:1643] |
| Ensembl ID | ENSG00000012124 |
| Bio databases IDs | |
| Aliases | CD22 molecule, sialic acid binding Ig-like lectin 2 |
| Synonyms | A530093D23, CD22 antigen, Cd22-beta, CD22 molecule, Cd22-β, FLJ22814, Lyb-8, SIGLEC-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- immunoglobulin domain
- protein phosphatase binding
- Immunoglobulin I-set domain
- signal peptide
- central domain
- protein binding
- receptor binding
- immunoglobulin binding
- CD4 receptor binding
- T-cell surface glycoprotein CD3 delta chain
- membrane distal domain
- binding protein
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin like
- sialic acid-binding domain
- immunoglobulin-like protein domain
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the CD22 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- T acute lymphoblastic leukemia
- precursor B-cell acute lymphoblastic leukemia
- lymphoma
- colorectal cancer
- systemic lupus erythematosus
- overall survival
- contact hypersensitivity
- multiple system atrophy
- acute lymphoblastic leukemia
role in cell
- apoptosis
- expression in
- cell death
- phosphorylation in
- activation
- response
- proliferation
- migration
- formation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- cell-cell contacts
- plasma membrane extracellular face
- microdomains
- recycling endosomes
- early endosomes
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of B cell proliferation
- negative regulation of calcium-mediated signaling
- negative regulation of immunoglobulin production
- negative regulation of B cell receptor signaling pathway
- cell adhesion
- regulation of endocytosis
- B cell activation
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- early endosome
- extracellular vesicular exosome
- cytoplasm
- membrane
- external side of plasma membrane
- neuronal cell body membrane
- recycling endosome
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- protein binding
- CD4 receptor binding
- sialic acid binding
- carbohydrate binding
- IgM binding
- receptor binding