TLR6 Gene Summary [Human]
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | TLR6 |
| Official Name | toll like receptor 6 [Source:HGNC Symbol;Acc:HGNC:16711] |
| Ensembl ID | ENSG00000174130 |
| Bio databases IDs | |
| Aliases | toll like receptor 6 |
| Synonyms | CD286, toll-like receptor 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TLR6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- lipid binding
- protein phosphatase 1 regulatory subunit 42
- signaling receptor activity
- diacylated lipoprotein binding
- SEFIR domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
- receptor binding
- TIR domain
- identical protein binding
- leucine-rich repeat
- binding protein
- cytoplasmic domain
- transmembrane domain
- intracellular domain
- transmembrane receptor
- protein heterodimerization
Pathways
Biological processes and signaling networks where the TLR6 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Toll-like Receptor Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- susceptibility to paucibacillary type leprosy
- organismal death
- lepromatous leprosy
- renal clear cell adenocarcinoma
- renal clear cell cancer
- chronic lymphocytic leukemia
role in cell
- expression in
- phosphorylation in
- binding in
- growth
- differentiation
- apoptosis
- function
- activation
- production in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Golgi Apparatus
- membrane rafts
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TLR6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric oxide biosynthetic process
- positive regulation of JUN kinase activity
- activation of NF-kappaB-inducing kinase activity
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- detection of diacyl bacterial lipopeptide
- positive regulation of cytokine production involved in inflammatory response
- inflammatory response
- MyD88-dependent toll-like receptor signaling pathway
- immune response
- positive regulation of macrophage activation
- toll-like receptor TLR6:TLR2 signaling pathway
- signal transduction
- positive regulation of NLRP3 inflammasome complex assembly
- defense response to bacterium
- nitric oxide metabolic process
- toll-like receptor signaling pathway
- microglial cell activation
- positive regulation of gene expression
- negative regulation of interleukin-8 production
- innate immune response
- positive regulation of extrinsic apoptotic signaling pathway
- negative regulation of toll-like receptor 2 signaling pathway
- positive regulation of interleukin-6 production
- cellular response to diacyl bacterial lipopeptide
- positive regulation of interleukin-1 beta production
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- Toll-like receptor 2-Toll-like receptor 6 protein complex
- membrane raft
- phagocytic vesicle membrane
- Golgi apparatus
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- Toll-like receptor 2 binding
- transmembrane signaling receptor activity
- protein binding
- protein heterodimerization activity
- signaling receptor activity
- receptor binding
- beta-amyloid binding
- lipopeptide binding