MVP Gene Summary [Human]
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | MVP |
| Official Name | major vault protein [Source:HGNC Symbol;Acc:HGNC:7531] |
| Ensembl ID | ENSG00000013364 |
| Bio databases IDs | |
| Aliases | major vault protein, lung resistance-related protein |
| Synonyms | 2310009M24Rik, LRP, major vault, major vault protein, VAULT1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MVP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- Major Vault Protein Repeat domain
- SPFH_like
- protein kinase binding
- Ezrin/radixin/moesin, alpha-helical domain
- protein phosphatase binding
- coiled-coil domain
- protein binding
- Shoulder domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- bone resorption disorder
- rheumatoid arthritis
- osteoporosis
- dysferlinopathy
- osteopenia
- early onset hypertension
role in cell
- proliferation
- expression in
- cell viability
- apoptosis
- phosphorylation in
- survival
- osteoclastogenesis
- signaling by
- recruitment in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribonucleoprotein fractions
- microsomal fraction
- nuclear fraction
- extracellular vesicles
- secretory granule lumen
- ficolin-1-rich granule lumen
- cytoskeleton
- Cytoplasm
- Extracellular Space
- cell periphery
- perinuclear region
- Plasma Membrane
- cytosol
- synaptic vesicles
- neurites
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MVP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- ERBB signaling pathway
- protein activation cascade
- protein transport
- negative regulation of protein tyrosine kinase activity
- negative regulation of epidermal growth factor receptor signaling pathway
- negative regulation of protein autophosphorylation
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- membrane
- cytosol
- secretory granule lumen
- extracellular region
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein phosphatase binding
- protein binding