Mvp Gene Summary [Rat]
Predicted to enable identical protein binding activity; protein kinase binding activity; and protein phosphatase binding activity. Predicted to be involved in several processes, including negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein phosphorylation; and protein activation cascade. Predicted to be located in cytoskeleton; cytosol; and perinuclear region of cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MVP (major vault protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mvp |
| Official Name | major vault protein [Source:RGD Symbol;Acc:70932] |
| Ensembl ID | ENSRNOG00000020182 |
| Bio databases IDs | |
| Aliases | major vault protein |
| Synonyms | 2310009M24Rik, LRP, major vault, major vault protein, VAULT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mvp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- Major Vault Protein Repeat domain
- SPFH_like
- protein kinase binding
- Ezrin/radixin/moesin, alpha-helical domain
- protein phosphatase binding
- coiled-coil domain
- protein binding
- Shoulder domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- bone resorption disorder
- rheumatoid arthritis
- osteoporosis
- dysferlinopathy
- osteopenia
- early onset hypertension
role in cell
- proliferation
- expression in
- cell viability
- apoptosis
- phosphorylation in
- survival
- osteoclastogenesis
- signaling by
- recruitment in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribonucleoprotein fractions
- microsomal fraction
- nuclear fraction
- extracellular vesicles
- secretory granule lumen
- ficolin-1-rich granule lumen
- cytoskeleton
- Cytoplasm
- Extracellular Space
- cell periphery
- perinuclear region
- Plasma Membrane
- cytosol
- synaptic vesicles
- neurites
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mvp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- ERBB signaling pathway
- protein activation cascade
- protein transport
- negative regulation of protein tyrosine kinase activity
- negative regulation of epidermal growth factor receptor signaling pathway
- negative regulation of protein autophosphorylation
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- membrane
- cytosol
- secretory granule lumen
- extracellular region
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein phosphatase binding
- protein binding