WNT8A
WNT8A Gene Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | WNT8A |
| Official Name | Wnt family member 8A [Source:HGNC Symbol;Acc:HGNC:12788] |
| Ensembl ID | ENSG00000061492 |
| Bio databases IDs | |
| Aliases | Wnt family member 8A |
| Synonyms | Stra11,wingless-type MMTV integration site family, member 8A,WNT8D,Wnt family member 8A |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- receptor agonist activity
- protein binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the WNT8A gene plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- RAR Activation
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- WLS
- TMPPE
- CTNNB1
- STS
- KCNJ8
- LNX1
- SUZ12
- SFRP1
- EZH2
- AFM
disease
- atrial fibrillation
regulated by
- doxorubicin
- TP53
- STK40
- WNT3A
- PRDX5
- METTL1
- tazemetostat
- YAF2
- INHBA
- BMP4
regulates
role in cell
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the WNT8A gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- anterior/posterior axis specification
- response to retinoic acid
- neural crest cell fate commitment
- neuron differentiation
- cell fate commitment
- canonical Wnt receptor signaling pathway
- dorsal/ventral axis specification
- positive regulation of transcription from RNA polymerase II promoter
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- frizzled binding
- receptor agonist activity
- cytokine activity