MNAT1 Gene Summary [Human]
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Details
| Type | Processed Transcript |
| Official Symbol | MNAT1 |
| Official Name | MNAT1 component of CDK activating kinase [Source:HGNC Symbol;Acc:HGNC:7181] |
| Ensembl ID | ENSG00000020426 |
| Bio databases IDs | |
| Aliases | MNAT1 component of CDK activating kinase, CDK-activating kinase assembly factor |
| Synonyms | CAK ASSEMBLY FACTOR, CAP35, E130115E11RIK, MAT1, menage a trois 1, MNAT1 component of CDK activating kinase, P36, RNF66, TFB3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MNAT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- CDK-activating kinase assembly factor MAT1
- coiled-coil domain
- protein binding
- hydrophobic domain
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the MNAT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- progressive vision loss
- cleft palate
- cleft lip
- rheumatoid arthritis
role in cell
- apoptosis
- proliferation
- outgrowth
- tanespimycin sensitivity
- replication in
- G1 phase
- G1/S phase transition
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromosome
- nucleoplasm
- germinal vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MNAT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell proliferation
- ventricular system development
- DNA repair
- negative regulation of apoptotic process
- response to calcium ion
- G1/S transition of mitotic cell cycle
- nucleotide-excision repair
- regulation of G1/S transition of mitotic cell cycle
- transcription initiation from RNA polymerase II promoter
- adult heart development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- core TFIIH complex
- cyclin-dependent protein kinase holoenzyme complex
- TFIIK complex
- holo TFIIH complex
- CAK-ERCC2 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding