TRIM34 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | TRIM34 |
| Official Name | tripartite motif containing 34 [Source:HGNC Symbol;Acc:HGNC:10063] |
| Ensembl ID | ENSG00000258659 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 34 |
| Synonyms | IFP1, RNF21, tripartite motif-containing 34 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- TPR/MLP1/MLP2-like protein
- B-Box C-terminal domain
- SPRY domain
- zinc finger of C3HC4-type, RING
- Ring finger domain
- identical protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- astrocytoma
- oligodendroglioma
- glioma formation
- organismal death
- oligoastrocytoma
- glioma
- idiopathic inflammatory myopathy
- low-grade glioma
- varicocele
role in cell
- activation in
- molecular cleavage in
- cell death
- restriction in
- replication in
- K63 polyubiquitination in
- focus formation in
- focus formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- regulation of viral entry into host cell
- regulation of protein localization
- protein polyubiquitination
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- defense response to virus
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- zinc ion binding
- protein homodimerization activity