PDCD10 Gene Summary [Human]
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PDCD10 |
| Official Name | programmed cell death 10 [Source:HGNC Symbol;Acc:HGNC:8761] |
| Ensembl ID | ENSG00000114209 |
| Bio databases IDs | |
| Aliases | programmed cell death 10 |
| Synonyms | 2410003B13Rik, CCM3, MGC72992, programmed cell death 10, Tfa15, TFAR15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCD10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF1241)
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- cerebral cavernous malformations 3
- cerebral cavernous malformation
- hereditary disorder
- familial cerebral cavernous malformation
- prostate cancer
- cerebral cavernous malformations 1
- vascular malformation
- anemia
- bleeding
role in cell
- expression in
- apoptosis
- proliferation
- accumulation in
- phosphorylation in
- quantity
- formation
- migration
- polarization
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- Golgi Apparatus
- cytosol
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCD10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- wound healing, spreading of cells
- regulation of Rho protein signal transduction
- positive regulation of intracellular protein transport
- Golgi reassembly
- positive regulation of cell proliferation
- regulation of angiogenesis
- stress fiber assembly
- negative regulation of cell migration involved in sprouting angiogenesis
- positive regulation of Notch signaling pathway
- endothelium development
- negative regulation of gene expression
- establishment of Golgi localization
- angiogenesis
- positive regulation of gene expression
- negative regulation of apoptotic process
- protein stabilization
- positive regulation of protein serine/threonine kinase activity
- intracellular signal transduction
- positive regulation of stress-activated MAPK cascade
- positive regulation of cell migration
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- Golgi membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein homodimerization activity
- protein binding