ANAPC4 Gene Summary [Human]
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | ANAPC4 |
| Official Name | anaphase promoting complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:19990] |
| Ensembl ID | ENSG00000053900 |
| Bio databases IDs | |
| Aliases | anaphase promoting complex subunit 4 |
| Synonyms | 2610306D21Rik, anaphase promoting complex subunit 4, APC4, D5ERTD249E, LOC108353762 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANAPC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- protein phosphatase binding
- ubiquitin-protein transferase activity
- Anaphase-promoting complex, cyclosome, subunit 4
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the ANAPC4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- post-traumatic stress disorder
- metabolic syndrome X
- obesity
- insomnia
- pervasive developmental disorder
- overnutrition
- primary snoring
- rheumatoid arthritis
- headache
role in cell
- cell viability
- degradation in
- mitotic exit in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANAPC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of meiotic cell cycle
- regulation of mitotic metaphase/anaphase transition
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- anaphase-promoting complex
- cytosol
- nuclear periphery
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- protein phosphatase binding