IL17RB Gene Summary [Human]
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL17RB |
| Official Name | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] |
| Ensembl ID | ENSG00000056736 |
| Bio databases IDs | |
| Aliases | interleukin 17 receptor B |
| Synonyms | CRL4, EVI27, IL17BR, IL-17B receptor, IL-17ER, IL-17Rh1, IL25R, interleukin 17 receptor B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL17RB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Interleukin 17 receptor D
- Interleukin-17 receptor, fibronectin-III-like domain 1
- SEFIR domain
- protein binding
- cytokine receptor
- transmembrane receptor
- SEFIR domain helix alphaC
Pathways
Biological processes and signaling networks where the IL17RB gene in human plays a role, providing insight into its function and relevance in health or disease.
- FAK Signaling
- Glucocorticoid Receptor Signaling
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-17A Signaling in Gastric Cells
- Role of IL-17A in Arthritis
- Role of IL-17A in Psoriasis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- STAT3 Pathway
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- systemic lupus erythematosus
- lymphomagenesis
- psoriasis
- colitis
- organismal death
- asthma
- RUNX1-RUNX1T1 positive acute myeloid leukemia
- Churg-Strauss syndrome
- atopic dermatitis
role in cell
- accumulation
- apoptosis
- expression in
- recruitment
- production in
- growth
- binding in
- signaling in
- cellular infiltration by
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL17RB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell growth
- cytokine-mediated signaling pathway
- defense response
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine receptor activity
- interleukin-17 receptor activity