IL17B Gene Summary [Human]
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
Details
| Type | Processed Transcript |
| Official Symbol | IL17B |
| Official Name | interleukin 17B [Source:HGNC Symbol;Acc:HGNC:5982] |
| Ensembl ID | ENSG00000127743 |
| Bio databases IDs | |
| Aliases | interleukin 17B, neuronal interleukin-17-related factor |
| Synonyms | 1110006O16Rik, 1700006N07RIK, IL-20, interleukin 17B, NIRF, ZCYTO7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL17B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor binding
- Interleukin-17
- cytokine
Pathways
Biological processes and signaling networks where the IL17B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- muscle invasive bladder cancer
- MLL translocation acute lymphocytic leukemia
- airway hyperresponsiveness
- CBFB-MYH11 acute myeloid leukemia
- RUNX1-RUNX1T1 positive acute myeloid leukemia
- sporadic amyotrophic lateral sclerosis
- leiomyosarcoma
- soft tissue sarcoma cancer
- psoriasis
- uterine leiomyoma
role in cell
- differentiation
- growth
- expression in
- migration
- apoptosis
- signaling in
- phosphorylation in
- activation in
- binding in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL17B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- signal transduction
- cell-cell signaling
- positive regulation of cytokine production involved in inflammatory response
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- cytokine activity