HAGH Gene Summary [Human]
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Details
| Type | Protein Coding |
| Official Symbol | HAGH |
| Official Name | hydroxyacylglutathione hydrolase [Source:HGNC Symbol;Acc:HGNC:4805] |
| Ensembl ID | ENSG00000063854 |
| Bio databases IDs | |
| Aliases | hydroxyacylglutathione hydrolase |
| Synonyms | GLO2, GLO2D, Glutathione Hydrolase, GLX2, GLXII, Glyoxalase II, HAGH1, Hydroxyacylglutathione hydrolase, RSP29 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HAGH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydroxyacylglutathione hydrolase
- Metallo-beta-lactamase superfamily
- Hydroxyacylglutathione hydrolase C-terminus
- enzyme
- protein binding
- metallo-hydrolase-like_MBL-fold
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- renal cell cancer
- proximal tubular toxicity
- preeclampsia
- breast carcinoma
regulates
- glutathione
- D-lactic acid
- S-(alpha-mandeloyl)glutathione
- S-(2-hydroxyacyl)glutathione
- S-lactoylglutathione
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HAGH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione metabolic process
- methylglyoxal catabolic process to D-lactate
- glutathione biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- hydroxyacylglutathione hydrolase activity
- protein binding
- metal ion binding