Hagh Gene Summary [Mouse]
Enables hydroxyacylglutathione hydrolase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to act upstream of or within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hagh |
| Official Name | hydroxyacyl glutathione hydrolase [Source:MGI Symbol;Acc:MGI:95745] |
| Ensembl ID | ENSMUSG00000024158 |
| Bio databases IDs | |
| Aliases | hydroxyacyl glutathione hydrolase |
| Synonyms | GLO2, GLO2D, Glutathione Hydrolase, GLX2, GLXII, Glyoxalase II, HAGH1, Hydroxyacylglutathione hydrolase, RSP29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hagh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydroxyacylglutathione hydrolase
- Metallo-beta-lactamase superfamily
- Hydroxyacylglutathione hydrolase C-terminus
- enzyme
- protein binding
- metallo-hydrolase-like_MBL-fold
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- renal cell cancer
- proximal tubular toxicity
- preeclampsia
- breast carcinoma
regulates
- glutathione
- D-lactic acid
- S-(alpha-mandeloyl)glutathione
- S-(2-hydroxyacyl)glutathione
- S-lactoylglutathione
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hagh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione metabolic process
- methylglyoxal catabolic process to D-lactate
- glutathione biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- hydroxyacylglutathione hydrolase activity
- protein binding
- metal ion binding