PLA2R1 Gene Summary [Human]
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Details
| Type | Processed Transcript |
| Official Symbol | PLA2R1 |
| Official Name | phospholipase A2 receptor 1 [Source:HGNC Symbol;Acc:HGNC:9042] |
| Ensembl ID | ENSG00000153246 |
| Bio databases IDs | |
| Aliases | phospholipase A2 receptor 1 |
| Synonyms | CLEC13C, Endo180, LOC102553743, M-type PLA2 receptor, M-type SPLA2, phospholipase A2 receptor 1, PLA2G1BR, PLA2G1R, PLA2IR, PLA2-R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLA2R1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- beta-trefoil_Ricin_MRC-like
- enzyme binding
- phospholipase A2 inhibitor
- FN2
- transmembrane receptor
Pathways
Biological processes and signaling networks where the PLA2R1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- neoplastic cell transformation
- inflammatory bowel disease
- idiopathic membranous nephropathy
- diabetic nephropathy
- membranous glomerulonephritis
- tumorigenesis
- Crohn disease
- HER2 negative hormone receptor negative breast cancer
role in cell
- expression in
- activation in
- number
- quantity
- invasion
- production in
- cell death
- oncogene-induced senescence
- cellular infiltration by
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLA2R1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oxidative stress-induced premature senescence
- positive regulation of arachidonic acid secretion
- reactive oxygen species metabolic process
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- replicative senescence
- negative regulation of arachidonic acid secretion
- positive regulation of cytokine production
- negative regulation of phospholipase A2 activity
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- receptor complex
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity
- phospholipase binding
- carbohydrate binding